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INPP5J Antibody

  • 中文名稱:
    INPP5J兔多克隆抗體
  • 貨號(hào):
    CSB-PA620891ESR1HU
  • 規(guī)格:
    ¥440
  • 促銷:
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA620891ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA620891ESR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) INPP5J Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    INPP5J antibody; PIB5PA antibody; PIPP antibody; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A antibody; EC 3.1.3.56 antibody; Inositol polyphosphate 5-phosphatase J antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A protein (60-360AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles.
  • 基因功能參考文獻(xiàn):
    1. Suggest miR-661 functions as a tumor promoter by targeting the INPP5J gene, and then promoting cell proliferation of ovarian cancer cells. PMID: 26282217
    2. Findings indicate inositol polyphosphate 5-phosphatase PIPP (INPP5J) as a suppressor of oncogenic phosphoinositide 3-kinase (PI3K)/AKT signaling in breast cancer. PMID: 26267533
    3. miR-508 has a role in sustaining phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma by suppressing INPP5J PMID: 25099196
    4. these results establish the tumour suppressive role of phosphatidylinositol 4,5-bisphosphate 5-phosphatase and reveal mechanisms involved in its downregulation in melanoma. PMID: 23443536
  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Inositol 1,4,5-trisphosphate 5-phosphatase type II family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8956

    OMIM: 606481

    KEGG: hsa:27124

    STRING: 9606.ENSP00000384534

    UniGene: Hs.517549