INPP5K Antibody
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中文名稱:INPP5K兔多克隆抗體
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貨號(hào):CSB-PA011740GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:43 kDa form skeletal muscle and kidney enriched inositol phosphatase antibody; Inositol polyphosphate 5-phosphatase K antibody; INP5K_HUMAN antibody; INPP5K antibody; muscle and kidney-enriched inositol phosphatase antibody; PPS antibody; skeletal muscle and kidney enriched inositol phosphatase antibody; Skeletal muscle and kidney-enriched inositol phosphatase antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Human INPP5K
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB
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Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
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基因功能參考文獻(xiàn):
- the distribution of genotype frequency exhibited no significant differences between the Parkinson's disease and control groups (P > 0.025) in INPP5K rs1109303 (P = 0.048, OR = 0.806, 95%CI = 0.650 - 0.998). PMID: 29607885
- In individuals exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability but normal cranial magnetic resonance imaging, we identified bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K. PMID: 28190456
- Mutations in INPP5K cause a congenital muscular dystrophy syndrome with short stature, cataracts, and intellectual disability. PMID: 28190459
- These findings suggest a model by which GRP78 regulates intracellular localization of SKIP and how SKIP binds to Pak1 on insulin stimulation. PMID: 26940976
- Study reveals that SKIP is a significant regulator of glioblastoma cell migration and that increased expression of SKIP may confer a survival advantage. PMID: 25241900
- SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis. PMID: 22815484
- Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1. PMID: 22751929
- identification of novel domain that mediates membrane ruffle localization PMID: 12536145
- The authors report that HBV core protein interacts with a cellular SKIP (skeletal muscle and kidney enriched inositol phosphatase) protein, an endoplasmic reticulum-located phosphoinositide 5-phosphatase, both in vivo and in vitro. PMID: 18774950
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相關(guān)疾?。?/div>Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)亞細(xì)胞定位:Endoplasmic reticulum. Cytoplasm.蛋白家族:Inositol 1,4,5-trisphosphate 5-phosphatase type II family組織特異性:Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.數(shù)據(jù)庫鏈接:
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