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IRX3 Antibody

  • 中文名稱(chēng)：
    IRX3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA090661
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IRX3 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) IRX3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    IRX3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human IRX3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類(lèi)型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
  • 基因功能參考文獻(xiàn)：
    1. IRX3 genetic variants associate with birth weight, body mass index and AST/ALT-related transaminase metabolism, supporting the role of IRX3 as an obesity-associated susceptibility gene. PMID: 28316138
    2. Results show that IRX3 deficiency repressed the browning program of white adipocytes partially by regulating UCP1 transcriptional activity. Rare variants of IRX3 were associated with human obesity. PMID: 28988979
    3. Increased adipocyte-specific expression of IRX3 correlates with the presence of the FTO obesity risk haplotype in lean children, whereas it was unaffected by risk variants in obese peers. IRX3 expression in adipocytes was significantly related to adipocyte hypertrophy. PMID: 27560134
    4. Downregulation of miR-377 may contribute to the upregulation of IRX3 in HCC. PMID: 27222047
    5. Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis. PMID: 25512384
    6. IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes. PMID: 20080751

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14360

    OMIM: 612985

    KEGG: hsa:79191

    STRING: 9606.ENSP00000331608

    UniGene: Hs.499205