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ITGA8 Antibody, HRP conjugated

  • 中文名稱：
    ITGA8兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA011871NB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ITGA8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Integrin alpha 8 antibody; Integrin alpha-8 heavy chain antibody; Integrin alpha-8 light chain antibody; ITA8_HUMAN antibody; ITGA 8 antibody; ITGA8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Peptide sequence from Human Integrin alpha-8 protein (114-131AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
  • 基因功能參考文獻：
    1. ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma patients PMID: 26198048
    2. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
    3. Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. PMID: 24439109
    4. the ITGA8 gene might have gender-specific roles in the development of schizophrenia. PMID: 23153507
    5. Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region. PMID: 23142384
    6. The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues. PMID: 20942236
    7. alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance. PMID: 20678483
    8. expressed in developing kidney PMID: 12060755
    9. Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. PMID: 12787402
    10. genomic analysis of the human integrin subunit alpha8 gene PMID: 15579315
    11. Mammary carcinoma cells do express alpha8 integrin. PMID: 15592496
    12. A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD. PMID: 18277079
    13. These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence. PMID: 19342381
    14. In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism. PMID: 19527220

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  • 相關疾病：
    Renal hypodysplasia/aplasia 1 (RHDA1)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Cell membrane.
  • 蛋白家族：
    Integrin alpha chain family
  • 組織特異性：
    Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6144

    OMIM: 191830

    KEGG: hsa:8516

    STRING: 9606.ENSP00000367316

    UniGene: Hs.171311