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ITM2A Antibody, Biotin conjugated

  • 中文名稱：
    ITM2A兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA011903LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ITM2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ITM2A
  • 別名：
    ITM2A; UNQ603/PRO1189; Integral membrane protein 2A; Protein E25
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Integral membrane protein 2A protein (79-263AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻(xiàn)：
    1. ITM2A might be a susceptibility gene for Graves disease in the Xq21.1 locus, and environmental factors, such as viral and bacterial infections, probably contribute to GD pathogenesis by interacting with the risk SNP rs3827440 mediating the regulation of ITM2A expression. PMID: 27809695
    2. ITM2A is a new biomarker of poor prognosis in ovarian cancer and a novel tumor suppressor that induces cell cycle arrest, acts as a chemosensitizer, and has therapeutic potential for ovarian cancer. PMID: 26691219
    3. The upregulated gene with the largest effect size in ankylosing spondylitis was ITM2A, which plays a role in activation of T cells. (Meta-analysis) PMID: 26125709
    4. ITM2A expression is positively regulated by PKA-CREB signaling and ITM2A expression interferes with autophagic flux by interacting with vacuolar ATPase. PMID: 25951193
    5. our results show one of the first links between phenotypic variation in a population sample and an XCI-escaping locus and pinpoint ITM2A as a potential contributor to the sexual dimorphism in height PMID: 24516404
    6. Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells. PMID: 19541402

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    ITM2 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6173

    OMIM: 300222

    KEGG: hsa:9452

    STRING: 9606.ENSP00000362395

    UniGene: Hs.17109