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中文名稱:JDP2兔多克隆抗體
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貨號:CSB-PA006988
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:JDP2
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別名:Jdp2 antibody; JDP2_HUMAN antibody; Jun dimerization protein 2 antibody; JUNDM2 antibody; Progesterone receptor co-activator antibody
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宿主:Rabbit
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反應種屬:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from Human JDP2 around the non-phosphorylation site of T148.
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應用范圍:WB, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
引用文獻
- High concentrations of progesterone inhibit the expression of genes related to steroid metabolism in MA-10 Leydig cells LS Izichkis, A Basque, LJ Martin,Molecular and Cellular Endocrinology,2024
相關(guān)產(chǎn)品
靶點詳情
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功能:Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
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基因功能參考文獻:
- In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC and better survival. PMID: 28315425
- Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells. PMID: 24120378
- Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE. PMID: 24232097
- the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism. PMID: 22989952
- The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed. PMID: 20950777
- JDP2 is crucial to triggering reactivation from latency to lytic replication PMID: 21525011
- 3 SNPs (2 intronic: rs741846 & rs175646; & 1 in the untranslated region: rs8215) & their genotype distribution showed significant association in the Japanese & Korean but not Dutch intracranial aneurysm patients. PMID: 20452405
- JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival. PMID: 20677166
- c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene PMID: 14627710
- JDP2 is a cellular survival protein whose presence is necessary for normal cellular function PMID: 16026868
- JDP2 acts as a repressor and could be functionally associated with HDAC3 to inhibit CHOP transcription PMID: 18396163
- IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter. PMID: 18671972
- A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain. PMID: 19553667
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亞細胞定位:Nucleus.
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蛋白家族:BZIP family, ATF subfamily
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