KCNA5 Antibody
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中文名稱(chēng):KCNA5兔多克隆抗體
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貨號(hào):CSB-PA003119
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:KCNA5
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別名:KCNA5; Potassium voltage-gated channel subfamily A member 5; HPCN1; Voltage-gated potassium channel HK2; Voltage-gated potassium channel subunit Kv1.5
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from the Internal region of Human KV1.5.
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:WB, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
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基因功能參考文獻(xiàn):
- Molecular dynamics simulations are employed to determine the inhibitory mechanisms of three drugs, 5-(4-phenoxybutoxy)psoralen (PAP-1), vernakalant, and flecainide, on the voltage-gated K(+) channel Kv1.5, a target for the treatment of cardiac arrhythmia. PMID: 29652491
- This study adds insights to the functional impact of KCNA5 mutations in modulating atrial contractile functions. PMID: 28803858
- In addition, as IKur is an atrial-specific channel and a number of IKur-selective blockers have been developed as anti-AF agents, this study also helps to understand some contradictory results on both pro- and anti-arrhythmic effects of blocking IKur. PMID: 28622331
- our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells. PMID: 27075359
- Putative binding sites for arachidonic acid on the human cardiac Kv 1.5 channel PMID: 26292661
- Studies demonstrate that DNA hypermethylation contributes to epigenetic repression of the KCNA5 locus and that the resulting suppression of the Kv1.5 ion channel supports cancer cell proliferation. PMID: 26573141
- Kv1.5 expression is increased in osteosarcoma cells and tissues and shRNA mediated silencing of Kv1.5 results in cell proliferation inhibition, cell cycle arrest, and induces cell apoptosis. PMID: 26569226
- Direct interaction with specific amino acids underlies the blocking action of propofol on voltage-gated hKv1.5 channel. PMID: 26256861
- demonstrate that PK treatment cleaved mature membrane-bound (75kDa) Kv1.5 channels at a single locus in the S1-S2 linker, producing 42-kDa N-terminal fragments and 33-kDa C-terminal fragments PMID: 26874203
- These results indicate that CHIP decreases the Kv1.5 protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70 PMID: 26232501
- The expression of Kv1.5 channel protein changes with atrial fibrillation but not with age, rheumatic heart diseases, and sex in atrial fibrillation. PMID: 25918274
- One KCNA5 variant, H463R, was a novel mutation; the histidine at codon 463 is located in the S5-pore loop, in the vicinity of the pore of KV1.5 subunit. The other variant, T527M, showed a gain-of-function effect with an enhanced steady-state activation. PMID: 26129877
- The KCNA5 promoter is marked in cancer cells with PcG-dependent chromatin repressive modifications that increase in hypoxia. PMID: 25435365
- Mutations in KCNA5 gene is not associated with pulmonary arterial hypertension. PMID: 24936649
- Protein kinase C inhibition results in a Kv 1.5 and Kv beta 1.3 pharmacology closer to Kv 1.5 channels PMID: 24946104
- Data do not indicate an important role of potassium voltage-gated channel shaker-related subfamily member 5 (KCNA5) as a sclerosis (SSc)-susceptibility factor or as a pulmonary arterial hypertension (PAH)-development genetic marker for SSc patients. PMID: 23270786
- These results indicate that low temperature exposure stabilizes the protein in the cellular organelles or on the plasma membrane, and modulates its maturation and trafficking, thus enhancing the currents of hKv1.5 and its trafficking defect mutants. PMID: 24663680
- Kv1.5 is a determinant of human B cell proliferation and migration, thereby identifying this channel as a new target for immunomodulation. PMID: 23847097
- Results identified gain and loss of function mutations which lead to increased and decreased potassium currents enhancing AF. PMID: 23264583
- AMPK is a potent regulator of Kv1.5. AMPK inhibits Kv1.5 presumably in part by activation of Nedd4- 2 with subsequent clearance of channel protein from the cell membrane. PMID: 23221389
- Incretin regulation of beta-cell function involves the acetylation of Kv1.5. PMID: 23390957
- Kv1.5 may play an important role in oxidative vascular endothelial injury PMID: 23185428
- Ethanol prologned the action potential duration in isolated myocardium, which may be due to inhibition of Kv1.5 channel currents. PMID: 21681339
- The experiments disclose a completely novel function of beta-catenin, i.e. the regulation of Kv1.5 channel activity. PMID: 22166221
- In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. PMID: 22053194
- Our data implicate abnormal atrial repolarization control due to variable TK signaling as a mechanism in familial AF and thereby suggest a role for modulation of this pathway in AF and its treatment. PMID: 20638934
- In Kv1.5 H+ and Ni2+ differentially enhance a slow inactivation process that involves at least two inactivated states and that resting inactivation is probably a close variant of slow inactivation. PMID: 20581043
- an association was found solely for Pulmonary arterial hypertension associated with Systemic Sclerosis in KCNA5 ((potassium voltage-gated channel subfamily A member 5) rs10744676 variants PMID: 20556823
- Kv1.5 channel is blocked by diphenyl phosphine oxide-1 PMID: 20184887
- KCNA5 T527M mutation exerted a predominant negative effect on potassium currents but no effect on the subcellular location of the encoded ion channel. PMID: 20646426
- Biolistically introduced exogenous voltage-gated potassium channel, Kv1.5, is functional and, like endogenous Kv1.5, localizes to the intercalated disc, where it is expressed at the surface of that structure. PMID: 20357183
- Anandamide structure may a determinant of cannabinoid receptor-independent modulation. PMID: 20133392
- Data support a role for the T1 domain in channel kinetics as well as in KCNA5 channel subcellular localization. PMID: 20018952
- Overexpression of Kv1.5 is associated with cancer. PMID: 20025600
- In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 or Kv3.2b channels and Kv1.5 Arg487Tyr/Val, but not wild-type channels. PMID: 19332619
- These findings expand the spectrum of mutations in KCNA5 linked to atrial fibrillation (AF) and provide new insight into the molecular mechanism involved in AF. PMID: 19343045
- characterization of a truncated form of Kv1.5 PMID: 12021261
- Modulation by protein kinase C activation: role of the Kvbeta1.2 subunit. PMID: 12130714
- co-localization of Kv1.5 with PSD95 at the cell surface is similarly independent of the canonical PDZ-binding motif PMID: 12435606
- Reduction in the activation energy for the inactivation transition from the open state underlies the inhibition of hKv1.5 Na(+) current at low pH. PMID: 12601085
- Kv1.5 potassium channel mRNA expression correlates with glioma entities and malignancy grades; expression is high in astrocytomas, moderate in oligodendrogliomas, and low in glioblastomas. PMID: 12850541
- multiple isoforms of SAP97 were identifed in human heart atrium specimens; isoforms were found to co-immunoprecipiate with hKv1.5; isoforms were found to have distinct effect on hKv1.5 current and spatial channel organization PMID: 12970345
- the destabilization or bending of the S6 alpha-helix of KV1.5 caused by the PXP motif apparently creates a flexible "hinge" that allows movement of the lower S6 segment during channel gating and opening PMID: 13679372
- No electrical remodeling is evident in Kv1.5DN-expressing ventricular myocytes, and the (Kv1.5DN-induced) elimination of IK,slow1 does not result in spontaneous ventricular arrhythmias. PMID: 14527939
- an examination of the effect of K channel blocker S0100176) on the structure of the Kv1.5 channel PMID: 14578345
- Overexpression of the human KCNA5 gene increases K+ currents (i.e., K+ efflux or loss), accelerates apoptotic volume decrease (AVD), increases caspase-3 activity, and induces apoptosis PMID: 15140747
- Heterologously expressed human pulmonary arterial smooth muscle cells (PASMC) Kv1.5 generated an O2- and correolide-sensitive I(K) like that in resistance PASMCs. PMID: 15217912
- There is a central role for developmentally regulated ductus arteriosus SMC O2-sensitive Kv channels in the functional closure of the DA. PMID: 15353504
- This suggests that for Kv channels, the coupling between voltage sensing and gating reflects primarily an intrasubunit interaction. PMID: 15623896
- P. 142: "An aligment of KCNA5 among human, mouse, and rat shows 86% amino acid identity, and no monogenicc human arrhythmia syndrome has been linked to KCNA5" PMID: 15735608
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相關(guān)疾病:Atrial fibrillation, familial, 7 (ATFB7)
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.5/KCNA5 sub-subfamily
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組織特異性:Pancreatic islets and insulinoma.
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