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KCNH1 Antibody

  • 中文名稱：
    KCNH1兔多克隆抗體
  • 貨號：
    CSB-PA012035DSR1HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA012035DSR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KCNH1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCNH1
  • 別名：
    EAG antibody; EAG channel 1 antibody; EAG1 antibody; Ether a go go potassium channel 1 antibody; Ether a go go, Drosophila, homolog of antibody; Ether-a-go-go potassium channel 1 antibody; ether-a-go-go, Drosophila, homolog of antibody; h eag antibody; h-eag antibody; hEAG1 antibody; Kcnh1 antibody; KCNH1_HUMAN antibody; Kv10.1 antibody; M eag antibody; MGC124419 antibody; MGC124420 antibody; MGC142269 antibody; Potassium voltage gated channel subfamily H (eag related), member 1 antibody; Potassium voltage gated channel subfamily H member 1 antibody; Potassium voltage-gated channel subfamily H member 1 antibody; Voltage gated potassium channel subunit Kv10.1 antibody; Voltage-gated potassium channel subunit Kv10.1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Potassium voltage-gated channel subfamily H member 1 protein (840-989AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs).
  • 基因功能參考文獻：
    1. the overexpression of Eag1 might be associated with an increased risk of progression to breast cancer PMID: 28070819
    2. A role of Kv10.1 in coordinating primary cilium disassembly with cell cycle progression through localized changes of membrane potential at the ciliary base is proposed [REVIEW]. PMID: 28370099
    3. in this report, we present two independent screening campaigns in which we wanted to identify small molecules that bind to either the intracellular cytoplasmic amino terminal Per-Arnt-Sim (PAS) domain from the human EAG-related gene (ERG) channel or the amino or carboxy terminal globular domains from the mouse EAG1 channel, affecting their interaction. PMID: 26975997
    4. REVIEW: Kv10.1 potassium channel: role from the brain to the tumors PMID: 28708947
    5. Crystal structure of the PAS domain of the hEAG potassium channel has been presented. PMID: 27487920
    6. KV10.1 localizes to the centrosome and the primary cilium and promotes ciliary disassembly. Interference with KV10.1 ciliary localization abolishes not only the effects on ciliary disassembly, but also KV10.1-induced tumor progression in vivo Conversely. PMID: 27113750
    7. Mibefradil binds to the voltage sensor domain of Kv10.1 channels, modifying the gating of the channels in a way that in some, but not all, aspects opposes the gating effects exerted by divalent cations. PMID: 27255432
    8. Eag1 potassium channels and miR34a are involved in the response to rotenone-induced injury in SHSY5Y cells. PMID: 28259991
    9. Simulations with the inactivation-enhancing mutant Y464A or Na(+) ions lead to trapped water molecules behind the SF, suggesting that these simulations captured early conformational changes linked to C-type inactivation PMID: 28109880
    10. The human EAG1 (hEAG1) channel is remarkably sensitive to inhibition by intracellular calcium (Ca(2+) i) through binding of Ca(2+)-calmodulin to three sites adjacent to the eagD and cNBHD. PMID: 27325704
    11. Structural, biochemical, and functional analysis of the calmodulin (CaM) binding sites within the EAG1 channel suggests that the molecular change induced by CaM and underlying channel inhibition occurs locally. PMID: 27618660
    12. Our report confirms that KCNH1 mutations are associated with syndromic neurodevelopmental disorder, and also support the functional importance of the S4 domain. PMID: 26818738
    13. Epilepsy is a key phenotypic feature in most individuals with KCNH1-related syndromes, suggesting a direct role of KCNH1 in epileptogenesis, although the underlying mechanism is not understood. PMID: 27267311
    14. Findings show that the hEAG1 channel is directly regulated by PIP2 and that this regulation may contribute to normal human physiology and pathology. PMID: 27005320
    15. direct link between hERG 1b mutation and cardiomyocyte dysfunction PMID: 26772437
    16. Expression of Kv10.1 driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells. PMID: 27029528
    17. Eag1 may serve as a potential indicator to predict tumor cell chemosensitivity. Silencing Eag1 may represent a potential therapeutic strategy to increase ovarian cancer sensitivity to cisplatin. PMID: 26079730
    18. The expression of Eag1 may be partially explained the aggressive behavior of triple negative breast cancer in the breast cancer tissue. PMID: 26823849
    19. Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway. PMID: 26783521
    20. Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase PMID: 26518875
    21. Repression by calcitriol occurs at the transcriptional level and involves a functional negative vitamin D response element (nVDRE) E-box type in the hEAG1 promoter. PMID: 25495694
    22. Astemizole might have clinical utility for HCC prevention and treatment, and Eag1 channels may be potential early Hepatocellular carcinoma biomarkers PMID: 25783527
    23. KCNH1 mutations cause Zimmermann-Laband syndrome. PMID: 25915598
    24. These results suggest that Eag1 plays an important role in regulating the proliferation and cell cycle of liposarcoma cells PMID: 25136578
    25. De novo KCNH1 mutations in exons 6 and 8 in Temple-Baraitser syndrome showed a decreased threshold of activation and delayed deactivation, leading to deleterious gain of function. PMID: 25420144
    26. the Eag1 channel plays a crucial role in regulating the proliferation and cell cycle of osteosarcoma cells, and represents a new and effective therapeutic target for osteosarcoma. PMID: 24694542
    27. hERG and hEAG channels are regulated by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain. PMID: 24587194
    28. Progesterone induced KCNH1 mRNA and protein expression in cells transfected with human progesterone receptor-B. PMID: 24062569
    29. The roles of Kv10.1 in oncology and the mechanisms that are responsible for its aberrant expression in tumor cells. [Review] PMID: 24336491
    30. our results suggest that miR-34a could inhibit osteosarcoma growth via the down regulation of Eag1 expression. PMID: 23569431
    31. Eag1 K+ channel and ErbB were expressed in all human pituitary adenomas examined while ErbB2 expression was more variable. PMID: 23413122
    32. The functional state of KCNH1 channels is determined by the oxidative status of these linkers that provide an additional dimension of channel regulation. PMID: 22310694
    33. Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1. PMID: 23144454
    34. MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-a-go-go (EAG1). PMID: 22999387
    35. calcitriol antiproliferative effects by downregulating CYP24A1, upregulating vitamin D receptor (VDR) and targeting Eag1. PMID: 22984610
    36. hEAG1 expression is a biologically relevant feature that promotes cell proliferation and invasion, although independently of its ion-conducting function. PMID: 22466864
    37. Mutation Y464A in the S6 segment leads to EAG1 inactivation that can be prevented by additional mutations located in the S5 segment (F359A) or pore helix (L434A). PMID: 22930803
    38. Silencing of Rabaptin-5 induces down-regulation of recycling of K(V)10.1 channel in transfected cells and reduction of K(V)10.1 current density in cells natively expressing K(V)10.1, indicating a role of Rabaptin-5 in channel trafficking. PMID: 22841712
    39. Human Eag1 may represent a target for the suppression of breast cancer cell migration, and thus prevention of metastasis development. PMID: 22495877
    40. inhibition of either expression or activity of Eag1 leads to reduced proliferation of cancer cells, making Eag1 a potential anticancer target. Using Eag1 in cancer detection programs could help to reduce mortality from this disease PMID: 22778627
    41. KCNH1-encoded human hEAG1 potassium channel plays an important role in regulating the proliferation of induced pluripotent stem cells (PSC)-mesenchymal stem cells (MSCs) and bone marrow (BM)-MSCs. PMID: 22357737
    42. Overexpression of potassium channel ether a go-go is associated with osteosarcoma. PMID: 22248279
    43. These results demonstrate that hEAG1 channel activity is regulated by EGFR kinase at the tyrosine residues Tyr90, Try344, and Try485. PMID: 22061963
    44. We suggest Eag1 as a potential marker of cervical dysplasia and a risk indicator for developing cervical lesions in patients taking estrogens PMID: 21887469
    45. K(V)10.1 channels at the nuclear envelope might participate in the homeostasis of nuclear K(+), or indirectly interact with heterochromatin, both factors known to affect gene expression PMID: 21559285
    46. Data suggest that to avoid the potential harmful side effect, hERG channel toxicity needs to be assessed in a timely and efficient fashion. PMID: 21320466
    47. High EAG1 potassium channels is associated with epithelial-to-mesenchymal transition in lung cancer. PMID: 21508374
    48. This study is the first to demonstrate that K(+) channels such as hEag1 are directly involved in the IGF-1-induced up-regulation of cyclin D1 and E expression in MCF-7 cells. PMID: 21315112
    49. a role for Eag as a prognostic marker for survival in patients with ovarian cancer PMID: 21138547
    50. This study suggests that the SNPs within the kcnh1 genes we examined do not play a major role in schizophrenia in the Han Chinese population. PMID: 20933057

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  • 相關(guān)疾病：
    Temple-Baraitser syndrome (TMBTS); Zimmermann-Laband syndrome 1 (ZLS1)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Early endosome membrane. Note=Perinuclear KCNH1 is located to NPC-free islands.
  • 蛋白家族：
    Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.1/KCNH1 sub-subfamily
  • 組織特異性：
    Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6250

    OMIM: 135500

    KEGG: hsa:3756

    STRING: 9606.ENSP00000271751

    UniGene: Hs.553187