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KCNMB3 Antibody, FITC conjugated

  • 中文名稱：
    KCNMB3兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA878838LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KCNMB3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    BK channel subunit beta 3 antibody; BK channel subunit beta-3 antibody; BKbeta 3 antibody; BKbeta3 antibody; Calcium activated potassium channel beta 3 subunit antibody; Calcium activated potassium channel subfamily M subunit beta 3 antibody; Calcium activated potassium channel subunit beta 3 antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta-3 antibody; Charybdotoxin receptor subunit beta 3 antibody; Charybdotoxin receptor subunit beta-3 antibody; EG435726 antibody; Gm5707 antibody; Hbeta 3 antibody; Hbeta3 antibody; K(VCA)beta 3 antibody; K(VCA)beta-3 antibody; KCMB3_HUMAN antibody; KCNMB 2 antibody; KCNMB 3 antibody; KCNMB2 antibody; KCNMB3 antibody; KCNMBL antibody; Large conductance voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit antibody; Maxi K channel subunit beta 3 antibody; Maxi K channel subunit beta-3 antibody; Potassium channel, calcium-activated large conductance, subfamily M, beta member 3 antibody; Potassium large conductance calcium activated channel beta 3 subunit antibody; Potassium large conductance calcium activated channel subfamily M beta member 3 antibody; Slo beta 3 antibody; Slo-beta-3 antibody; subfamily M subunit beta-3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Calcium-activated potassium channel subunit beta-3 protein (82-207AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
  • 基因功能參考文獻(xiàn)：
    1. Single-nucleotide polymorphism in KCNMB3 gene is associated with Insulin Resistance. PMID: 23826284
    2. The frequency of the delA750 mutation was significantly increased in idiopathic generalized epilepsy (7.9%) compared to that in the controls (5.5%; P = 0.016, one-sided; OR = 1.52; 95%-CI: 1.05-2.21). PMID: 16958040
    3. The KCNMB3 isoforms beta3a-d may have unique functions in primates. PMID: 18591419
  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    KCNMB (TC 8.A.14.1) family, KCNMB3 subfamily
  • 組織特異性：
    Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6287

    OMIM: 605222

    KEGG: hsa:27094

    STRING: 9606.ENSP00000319370

    UniGene: Hs.591285