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KIF6 Antibody

  • 中文名稱：
    KIF6兔多克隆抗體
  • 貨號(hào)：
    CSB-PA754540ESR1HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA754540ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA754540ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KIF6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    KIF6 antibody; C6orf102Kinesin-like protein KIF6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Kinesin-like protein KIF6 protein (565-814AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. The result suggests that KIF6 rs20455 polymorphism may not be associated with coronary heart disease susceptibility. (Meta-analysis) PMID: 29304815
    2. his represents the first study implicating KIF6 variants with obesity in men, and point to the possible involvement of this genetic locus in the known gender-related differences in coronary artery disease. PMID: 29295555
    3. The Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing myocardial infarction and that allele 719Arg may have a protective association to present coronary heart disease in all populations [review; meta-analysis] PMID: 28096762
    4. The absence of Trp719Arg polymorphism association with coronary artery disease (CAD) and CAD in stratified myocardial infarction cases indicates that the polymorphism is not associated with an increased risk among CAD patients from the Eastern Province of Saudi Arabia PMID: 26997531
    5. KIF6 polymorphism rs20455 had a significant association with Coronary Heart Disease; statin therapy was more effective in rs20455 carriers than non-carriers PMID: 26443250
    6. KIF6 719Arg allele may increase the risk of T2DM and T2DM + CHD only in Han Chinese men by modulating lipid metabolism. PMID: 25629058
    7. Our case-control study suggests that Trp719Arg of KIF6 gene is associated with coronary heart disease in female Han Chinese through a post hoc analysis. PMID: 23236363
    8. KIF6 719Arg allele was not an independent risk factor for angiographic coronary artery disease(CAD)susceptibility in northern China Han populations; it was associated with a significantly higher TG level, which may indicate increased myocardial infarction risk in angiographic CAD patients PMID: 23001387
    9. These data suggest that decreased availability of functional KLF6 contributes to clinical prostate cancer progression. PMID: 22819534
    10. In a meta-analysis involving 144,931 participants, the KIF6 719Arg allele was not associated with the relative risk of cardiovascular disease PMID: 22216121
    11. Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. PMID: 22192511
    12. Carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India. PMID: 21810021
    13. In patients with type 2 diabetes mellitus on hemodialysis, KIF6 Trp719Arg genotypes were not associated with adverse cardiovascular outcomes during follow-up or with the efficacy of atorvastatin therapy. PMID: 21871624
    14. Discovered influence of polymorphic marker Trp719Arg of KIF6 gene on individual response to therapy with 10 mg/day of atorvastatin. PMID: 21943003
    15. A combination of KIF6 719Arg carrier status and C-reactive protein levels modestly improves the prediction of risk of myocardial infarction among white men. PMID: 21406102
    16. Use of KIF6 genotyping to guide statin therapy is not warranted in this heart protection trial, since no impact is found on KIF6 genotype, vascular risk or statin response. PMID: 21458191
    17. Carriers of the KIF6 719Arg allele were not at increased risk of non-fatal myocardial infarction. PMID: 20927332
    18. three highly linked SNPs in the KIF6 region were identified that predict differential reduction of coronary events from statin therapy. PMID: 20886236
    19. review of data supporting association between KIF6 polymorphism and coronary heart disease (CHD) and association between KIF6 polymorphism and event reduction by statin therapy; discuss putative biologic role of this kinesin in the cause of CHD [review] PMID: 20854963
    20. the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins (Review) PMID: 20659029
    21. Observational study and clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20886236
    22. Observational study of gene-disease association. (HuGE Navigator) PMID: 20927332
    23. Meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20933357
    24. Elderly carriers of the KIF6 719Arg variant with prior vascular disease received significant benefit from pravastatin therapy. PMID: 20215968
    25. Kinesin-like protein-6 tryptophan719arginine polymorphism is not associated with risk of clinical coronary artery disease in this large replication study. PMID: 20933357
    26. a relationship between the presence of endothelial colony-forming cells and Arg/Arg genotype in KIF6 in patients with acute myocardial infarction. PMID: 20044086
    27. Observational study of gene-disease association. (HuGE Navigator) PMID: 20679960
    28. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    29. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20403483
    30. pravastatin therapy significantly and substantially reduced primary end point events in carriers of the KIF6 719Arg allele but not in noncarriers. PMID: 20403483
    31. Observational study of gene-disease association. (HuGE Navigator) PMID: 19752551
    32. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20215968
    33. In both the CARE and the WOSCOPS trials, carriers of the KIF6 719Arg allele had an increased risk of coronary events, and pravastatin treatment substantially reduced that risk. PMID: 18222353
    34. Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS. PMID: 18222354
    35. Carriers of 719Arg receive significantly greater benefit from intensive statin therapy than do noncarriers, a superior benefit that appears to be due to a mechanism distinct from lipid or CRP lowering. PMID: 18222355
    36. The KIF6 719Arg variant has been associated with an increased risk of coronary disease and an increased response to statin therapy. PMID: 18510970
    37. Observational study of gene-disease association. (HuGE Navigator) PMID: 19023099
    38. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 18222353
    39. Observational study of gene-disease association. (HuGE Navigator) PMID: 18222354
    40. Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18222355
    41. Observational study of gene-disease association. (HuGE Navigator) PMID: 17975119
    42. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18073581

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21202

    OMIM: 613919

    KEGG: hsa:221458

    STRING: 9606.ENSP00000287152

    UniGene: Hs.588202