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  4. KLHL21 Antibody

KLHL21 Antibody

  • 中文名稱：
    KLHL21兔多克隆抗體
  • 貨號(hào)：
    CSB-PA012423GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    KLHL21
  • 別名：
    Kelch-like protein 21 antibody; KIAA0469 antibody; KLH21_HUMAN antibody; KLHL21 antibody; MGC99635 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human KLHL21
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
  • 基因功能參考文獻(xiàn)：
    1. KLHL21 plays an essential role in the tumorigenesis and progression of cholangiocarcinoma. PMID: 29574153
    2. Our study suggests that KLHL21 is a potential target for therapeutic intervention. Our findings also provide novel candidate genes on a genome-wide scale, which may have significant impact on the design and execution of effective therapy of HCC patients. PMID: 27769251
    3. data clearly demonstrate that KLHL21 negatively regulates TNFalpha-activated NF-kappaB signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB regulation in cells. PMID: 27387502
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29041

    OMIM: 616262

    KEGG: hsa:9903

    STRING: 9606.ENSP00000366886

    UniGene: Hs.7764