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KPNA5 Antibody

  • 中文名稱(chēng)：
    KPNA5兔多克隆抗體
  • 貨號(hào)：
    CSB-PA012487GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    KPNA5
  • 別名：
    IMA5_HUMAN antibody; Importin alpha 6 antibody; Importin subunit alpha 6 antibody; Importin subunit alpha-6 antibody; IPOA 6 antibody; IPOA6 antibody; Karyopherin alpha 5 antibody; Karyopherin alpha 5 importin alpha 6 antibody; Karyopherin subunit alpha 5 antibody; Karyopherin subunit alpha-5 antibody; KPNA 5 antibody; KPNA5 antibody; SRP 6 antibody; SRP6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human KPNA5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
  • 基因功能參考文獻(xiàn)：
    1. eVP24 recognizes a unique nonclassical nuclear localization signal binding site on KPNA5 that is necessary for efficient phosphoryated STAT1 nuclear transport. PMID: 25121748
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Importin alpha family
  • 組織特異性：
    Testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6398

    OMIM: 604545

    KEGG: hsa:3841

    STRING: 9606.ENSP00000348704

    UniGene: Hs.182971