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LAMB3 Antibody

  • 中文名稱：
    LAMB3兔多克隆抗體
  • 貨號：
    CSB-PA678801
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human sarcoma tissue using CSB-PA678801(LAMB3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: CSB-PA678801(LAMB3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    BM600 125KDA antibody; Epiligrin subunit bata antibody; FLJ99565 antibody; Kalinin B1 chain antibody; Kalinin subunit beta antibody; LAM5 antibody; LAMB3 antibody; LAMB3_HUMAN antibody; Laminin B1k chain antibody; Laminin subunit beta-3 antibody; Laminin-5 subunit beta antibody; LAMNB1 antibody; Nicein subunit beta antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human LAMB3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻：
    1. From these results, it was shown that laminin-332 is an essential niche component for the proper differentiation of Interfollicular epidermal stem cells. PMID: 29555367
    2. the gentamicin-induced laminin beta3 led to the restoration of laminin 332 assembly, secretion, and deposition within the dermal/epidermal junction, as well as proper polarization of alpha6beta4 integrin in basal keratinocytes PMID: 29946029
    3. Results show three specific LAMB3 mutations: c.823-1G>A, c.957ins77 and c.3228+1G>A are carried by 91% of all LAMB3 alleles and that at least one of these three mutations will be carried in junctional epidermolysis bullosa individuals in this Chilean population. PMID: 27480391
    4. expression in preoperative biopsy material predictive of perineural invasion in patients with oral squamous cell carcinoma PMID: 27863864
    5. The authors have identified a mutation in LAM3 causing lethal epidermolysis bullosa in a Balkan, Hungarian, population. Investigations into the genetic background of its unique carrier group, suggests that the estimated age of the mutation corresponds to the period of Roma migration in the Balkans. PMID: 27062385
    6. the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298. Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells. PMID: 27698189
    7. The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer. PMID: 28653739
    8. Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity PMID: 27431458
    9. Case Reports: Junctional epidermolysis bullosa with LAMB3 splice-site mutations. PMID: 25708563
    10. LNbeta3 expression may play a key role in the progression and prognosis of pancreatic ductal adenocarcinoma. PMID: 25032755
    11. Screening of ENAM and LAMB3 genes was performed by direct sequencing of genomic DNA from blood samples. PMID: 25769099
    12. Case Report: linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies. PMID: 24978847
    13. An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set). PMID: 25867809
    14. Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity. PMID: 24494736
    15. we report a case of Herlitz junctional epidermolysis bullosa with a novel heterozygous mutation in LAMB3,c.1597G>A (p.Ala533Thr). PMID: 23278291
    16. However, to our knowledge, this is the first report of dominant AI due to a LAMB3 mutation in the absence of JEB. PMID: 23632796
    17. data further enhance the mutation spectrum of the LAMB3 and the COL7A1 genes, and also underscore the crucial roles of these genes in pathogenesis of epidermolysis bullosa PMID: 23769655
    18. an 8-bp deletion (c.3446_3453del GACTGGAG) shifting the reading frame (p.Gly 1149Glufs*8) and a single nucleotide substitution (c.C3431A) generating an in-frame translation termination codon (p.Ser1144*)associated with amelogenesis imperfecta PMID: 23958762
    19. Results identify the point during neoplastic progression in epithelia when the tumor suppressor p16 and laminin 5 are expressed and suggest that normal epithelia may use the same mechanism to generate non-dividing, motile cells for wound repair. PMID: 12875969
    20. Laminin-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma. PMID: 22898004
    21. These results suggest that epigenetic activation of LAMB3 and LAMC2 may play an important role in gastric carcinogenesis. PMID: 21345334
    22. The LAMB3 rs2566 variant CT/TT genotypes were associated with a significantly increased risk of cervical cancer, compared with the wild type CC genotype. PMID: 20163849
    23. Gene LAMB3 detected compound heterozygosity for the nonsense mutation R635X and a novel 2 bp deletion (1587delAG) resulting in a downstream premature termination codon. PMID: 11689492
    24. Deletion analysis of laminin-beta3 indicated that the region comprising aa 726 to 875 of laminin-beta3 interacts with rotavirus enterotoxin NSP4. PMID: 15331737
    25. In squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 beta3 chain is important in the invasiveness of cancer cells. PMID: 15363037
    26. homozygous frameshift mutation in LAMB3 was associated to illegitimate splicing leading to non-H junctional epidermolysis bullosa PMID: 15373767
    27. DNA analysis revealed a compound heterozygote for mutations 2379delG and Q995X in the LAMB3 gene in Herlitz junctional epidermolysis bullosa PMID: 16147969
    28. Multiple second-site mutations, all correcting the germline mutation LAMB3 (628G-->A;Glu210Lys), are present in 2 unrelated non-Herlitz junctional epidermolysis bullosa patients with revertant mosaicism. PMID: 17476356
    29. degradation [by Candida species] can exert functional disturbances on basement membrane integrity, possibly aiding Candida cell invasion into tissues PMID: 18284540
    30. The expression of LAMB3 mrna was higher in malignant tissue and correlated with the depth of invasion and venous invasion in ESCC. PMID: 18331784
    31. c.1945dupG mutation in Herlitz junctional epidermolysis bullosa PMID: 18387282
    32. Ln-332 gamma2 may be a therapeutic target against metastatic colon cancer because a lowered beta3:gamma2 ratio would reduce expression of heterotrimeric Ln-332 and increase monomeric gamma2 secretion. PMID: 19383890
    33. Histopathology of anti-laminin 5 mucous membrane pemphigoid is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils PMID: 19700013
    34. Results suggest that laminin (LN)gamma2 and LNbeta3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer. PMID: 19701966

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  • 相關(guān)疾病：
    Epidermolysis bullosa, junctional, Herlitz type (H-JEB); Generalized atrophic benign epidermolysis bullosa (GABEB); Amelogenesis imperfecta 1A (AI1A)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 組織特異性：
    Found in the basement membranes (major component).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6490

    OMIM: 104530

    KEGG: hsa:3914

    STRING: 9606.ENSP00000348384

    UniGene: Hs.497636