LAT2 Antibody
-
中文名稱:LAT2兔多克隆抗體
-
貨號(hào):CSB-PA012768GA01HU
-
規(guī)格:¥3,900
-
其他:
產(chǎn)品詳情
-
Uniprot No.:
-
基因名:LAT2
-
別名:HSPC046 antibody; LAB antibody; LAT2 antibody; Linker for activation of B cells antibody; Linker for activation of B-cells antibody; Linker for activation of T cells family member 2 antibody; Linker for activation of T cells transmembrane adaptor 2 antibody; Linker for activation of T-cells family member 2 antibody; Membrane associated adapter molecule antibody; Membrane-associated adapter molecule antibody; Non T cell activation linker antibody; Non-T-cell activation linker antibody; NTAL_HUMAN antibody; WBSCR 5 antibody; Wbscr15 antibody; Williams Beuren syndrome chromosome region 15 antibody; Williams Beuren syndrome chromosome region 5 antibody; Williams-Beuren syndrome chromosomal region 15 protein antibody; Williams-Beuren syndrome chromosomal region 5 protein antibody; WSCR5 antibody
-
宿主:Rabbit
-
反應(yīng)種屬:Human
-
免疫原:Human LAT2
-
免疫原種屬:Homo sapiens (Human)
-
抗體亞型:IgG
-
純化方式:Antigen Affinity Purified
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
-
產(chǎn)品提供形式:Liquid
-
應(yīng)用范圍:ELISA,WB,IHC
-
Protocols:
-
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
-
基因功能參考文獻(xiàn):
- Its overexpression represents a negative prognostic marker that has been linked to tumor grade, proliferating potential and angiogenesis and mediates intracellular transport of anticancer agents. PMID: 28815339
- The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells. PMID: 24456692
- LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy. PMID: 23001822
- NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK. PMID: 22269118
- LAB has the ability to modulate signaling in virtually every type of leukocyte. PMID: 20643813
- LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2-ERK-cPLA2 signalling cascade at early stages of H. pylori infection. PMID: 19879355
- data show that NTAL (non-T cell activation linker) appears to be a structural and possibly also functional homologue of LAT (linker for activation of T cells)in non-T cells [non-T cell activation linker] PMID: 12486104
- LAB links BCR engagement to downstream signaling pathways. PMID: 12514734
- LAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr(136), Tyr(193), and Tyr(233). Mutation of these three tyrosines abolished Grb2 binding and LAB function PMID: 14722116
- LAB resembled a LAT molecule unable to bind phospholipase C-gamma1. PMID: 15153499
- The NTAL/LAB is expressed in a variety of immune cells. PMID: 15745852
- NTAL acts as a negative regulator of TNF-alpha and IL-8 production after stimulation via TREM-1 PMID: 17277102
- observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated. PMID: 17993265
- These data show that natural killer cell immunoreceptor tyrosine-based activation motifs preferentially use a signaling cassette regulated by interplay between LAT and LAB. PMID: 18645037
- expression separates T lineage leukemias into two subgroups with good and poor prognostic outcome to prednisone therapy in acute lymphoblastic leukemia in children PMID: 19183565
顯示更多
收起更多
-
相關(guān)疾病:LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
-
亞細(xì)胞定位:Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
-
組織特異性:Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
-
數(shù)據(jù)庫(kù)鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-