LIPE Antibody, HRP conjugated
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中文名稱:LIPE兔多克隆抗體, HRP偶聯(lián)
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貨號:CSB-PA012975LB01HU
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) LIPE Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:Hormone sensitive lipase antibody; Hormone sensitive lipase testicular isoform antibody; Hormone-sensitive lipase antibody; HSL antibody; LHS antibody; Lipase hormone sensitive antibody; LIPE antibody; LIPS_HUMAN antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Hormone-sensitive lipase protein (1-251AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:HRP
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs. Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
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基因功能參考文獻:
- The homozygous null LIPE mutation could result in marked inhibition of lipolysis from some adipose tissue depots and thus may induce an extremely rare phenotype of MSL and partial lipodystrophy in adulthood associated with complications of insulin resistance, such as diabetes, hypertriglyceridemia and hepatic steatosis. PMID: 27862896
- Despite reductions in intramyocellular lipolysis and HSL expression, overexpression of HSL did not rescue defects in insulin action in skeletal myotubes from obese type 2 diabetic subjects. PMID: 25819461
- Identification of a homozygous nonsense variant p.Ala507fsTer563 in hormone sensitive lipase as the likely cause of the lipodystrophy phenotype in siblings. PMID: 25475467
- These findings indicate the physiological significance of HSL in adipocyte function and the regulation of systemic lipid and glucose homeostasis and underscore the severe metabolic consequences of impaired lipolysis. PMID: 24848981
- Serum triglyceride was significantly up-regulated in men with the (CG + GG) genotype of HSL promoter polymorphism. PMID: 23688034
- M. leprae suppresses lipid degradation through inhibition of HSL expression. PMID: 22553833
- Enzyme promiscuity in the hormone-sensitive lipase family of proteins. PMID: 21933124
- Resveratrol increased adipose triglyceride lipase gene and protein expressions, an effect that was not observed for hormone-sensitive lipase in human SGBS adipocytes. PMID: 21543206
- LIPE C-60G variation can inhibit the decrease of LDL-C and the increases of HDL-C and apo A-I in young healthy males, and can inhibit the decrease of LDL-C and the increase of insulin in young healthy females induced by a high-carbohydrate diet. PMID: 21826994
- suggests that genetic variation of HSL may be a risk factor for male infertility PMID: 21919688
- Data show that hormone-sensitive lipase activity is reduced in adipose tissue of patients with and without diabetes, while lipoprotein lipase activity is reduces only in patients with diabetes. PMID: 20926921
- It is concluded that ACTH via the PKA pathway stimulates expression of SF-1, which activates transcription of LIPE presumably by interaction with putative binding sequences within promoter A PMID: 21081692
- total lipase, ATGL and HSL activities were higher in visceral white adipose tissue of cancer patients compared with individuals without cancer and higher in cancer patients with cachexia compared with cancer patients without cachexia PMID: 21680814
- Data indicate that altered ATGL and HSL expression in skeletal muscle could promote DAG accumulation and disrupt insulin signaling and action. PMID: 21498783
- Studies indicate tha HSL is regulated by reversible phosphorylation on five critical residues. PMID: 21241784
- Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. PMID: 20495294
- The present study aimed at comparing expression and subcellular distribution of perilipin and hormone-sensitive lipase in two abdominal adipose tissues of lean and obese women. PMID: 20017959
- genes of C3, hormone-sensitive lipase, and PPARgamma may exert a modifying effect on lipid and glucose metabolism in familial combined hypersensitivity PMID: 11979403
- overexpression of HSL, despite increased lipase activity, does not lead to enhanced lipolysis PMID: 12518034
- HSL i6 A5 HOMOZYGOSITY IS A RISK FACTOR FOR BODY FAT ACCUMULATION PMID: 12534454
- high concentrations of estradiol significantly increased both hormone-sensitive lipase expression and glycerol release relative to control PMID: 12701046
- lipolytic catecholamine resistance of sc adipocytes in polycystic ovary syndrome is probably due to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of protein kinase A, and hormone-sensitive lipase PMID: 12727985
- High adrenaline levels can stimulate hormone-sensitive lipase(HSL) activity regardless of metabolic milieu. Large increases in adrenaline during exercise are able to further stimulate contraction-induced increase in HSL activity. PMID: 12730334
- The presence of a catalytically inactive variant of this enzyme is associated with decreased lipolysis in abdominal subcutaneous adipose tissue of obese subjects PMID: 12765952
- role of cyclic GMP in natriuretic peptide-mediated phosphorylation in adipocytes PMID: 12970365
- AMPK is a major regulator of skeletal muscle HSL activity that can override beta-adrenergic stimulation PMID: 15231718
- catalytic serine of hormone-sensitive lipase is highly reactive and similar behavior was also observed with lipases with no lid domain covering their active site, or with a deletion in the lid domain PMID: 15260473
- 5'AMP-activated protein kinase phosphorylates hormone-sensitive lipase on Ser565 in human skeletal muscle during exercise with reduced muscle glycogen. Apparently, HSL Ser565 phosphorylation by AMPK during exercise PMID: 15308678
- mechanism of infertility in HSL-deficient males is cell autonomous and resides in postmeiotic germ cells, because HSL expression in these cells is in itself sufficient to restore normal fertility PMID: 15345679
- a pre-lipolysis complex containing at least AFABP and HSL exists PMID: 15456755
- Basal HSL is decreased in patients with type 2 diabetes mellitus, and this may be a consequence of elevated plasma insulin levels. PMID: 15609025
- Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase PMID: 16243839
- the HSL C-60G polymorphism is associated with increased waist circumference in non-obese subjects PMID: 16534522
- adrenergic stimulation contributes to the increase in HSL activity that occurs in human skeletal muscle in the first minute of exercise at 65% and 90% VO2 peak PMID: 16690773
- HSL gene expression shows a regulation according to obesity status and is associated with increased adipose tissue lipase activity. PMID: 16752181
- although HSL expression and Ser(659) phosphorylation in skeletal muscle during exercise is sex specific, total muscle HSL activity measured in vitro was similar between sexes PMID: 16822962
- maternal type 1 diabetes is associated with TG accumulation and increased EL and HSL gene expression in placenta PMID: 16940551
- hormone-sensitive lipase PMID: 17026959
- Adipose triglyceride lipase and hormone sensitive lipase are responsible for more than 95% of the triacylglycerol hydrolase activity present in murine white adipose tissue. PMID: 17074755
- Adipose triglyceride lipase (ATGL) is less important than hormone-sensitive lipase (HSL) in regulating catecholamine-induced lipolysis. Both lipases regulate basal lipolysis in human adipocytes. ATGL expression is not influenced by obesity or PCOS. PMID: 17327373
- In obese subjects, insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression, independent of fat mass PMID: 17356053
- Dydrogesterone and norethisterone increase secretion of HSL from abdominaal adipocytes. PMID: 17587400
- variation of the HSL gene might be associated with a physiological effect on in vivo beta-adrenoceptor-mediated fat oxidation PMID: 18249203
- Real-time PCR revealed that large adipocytes expressed higher mRNA levels of hormone sensitive lipase. PMID: 18383440
- Obesity is accompanied by impaired fasting glycerol release, lower HSL protein expression, and serine phosphorylation. PMID: 18398140
- Mapping of the hormone-sensitive lipase binding site on the adipocyte fatty acid-binding protein (AFABP). Identification of the charge quartet on the AFABP/aP2 helix-turn-helix domain. PMID: 18820256
- analysis of human, mouse and ovine Hormone Sensitive Lipase PMID: 18824087
- PKA activates human HSL against lipid substrates in vitro primarily through phosphorylation of Ser649 and Ser650 PMID: 19018281
- These results suggest that the associations between physical activity and body fat and plasma lipoprotein/lipid concentrations in men are dependent on the LIPE C-60G polymorphism,. PMID: 19164092
- results suggest that ATGL/CGI-58 acts independently of HSL and precedes its action in the sequential hydrolysis of triglycerides in human hMADS adipocytes PMID: 19433586
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相關(guān)疾?。?/div>Lipodystrophy, familial partial, 6 (FPLD6)亞細胞定位:Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Lipid droplet.蛋白家族:'GDXG' lipolytic enzyme family組織特異性:Testis.數(shù)據(jù)庫鏈接:
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