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LMBR1L Antibody

  • 中文名稱：
    LMBR1L兔多克隆抗體
  • 貨號：
    CSB-PA012996GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    LMBR1L
  • 別名：
    LMBR1L antibody; KIAA1174 antibody; LIMR antibody; UNQ458/PRO783Protein LMBR1L antibody; Limb region 1 protein homolog-like antibody; Lipocalin-1-interacting membrane receptor antibody; LIMR antibody
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human LMBR1L
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway. In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels. Acts as a LCN1 receptor and can mediate its endocytosis.
  • 基因功能參考文獻：
    1. LIMR was shown to be highly specific for Lcn1, binding the lipocalin with low micromolar to high nanomolar affinity PMID: 23964685
    2. The receptor to which lipocalin binds is termed tear lipocalin-interacting membrane receptor and it appears to work by endocytosis. PMID: 21791187
    3. LIMR mediating internalization of lipocalin-1 (Lcn-1) in NT2 cells, leading to its degradation. PMID: 12591932
    4. Human LIMR, known to act as an endocytic receptor for lipocalin-1, also binds bovine BLG and mediates its cellular uptake. PMID: 17991420
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    LIMR family
  • 組織特異性：
    Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18268

    OMIM: 610007

    KEGG: hsa:55716

    UniGene: Hs.272838