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LRPAP1 Antibody, HRP conjugated

  • 中文名稱：
    LRPAP1兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA013104HB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LRPAP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    39 kDa receptor-associated protein antibody; A2MRAP antibody; A2RAP antibody; Alpha 2 macroglobulin receptor associated protein antibody; Alpha 2 MRAP antibody; Alpha-2-macroglobulin receptor-associated protein antibody; Alpha-2-MRAP antibody; AMRP_HUMAN antibody; HBP44 antibody; Lipoprotein receptor associated protein antibody; Low density lipoprotein receptor related protein associated protein 1 antibody; Low density lipoprotein receptor-related protein-associated protein 1 antibody; Low density lipoprotein related protein associated protein 1 alpha 2 macroglobulin receptor associated protein antibody; Low density lipoprotein related protein associated protein 1 antibody; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1) antibody; Lrpap1 antibody; MGC138272 antibody; MRAP antibody; MYP23 antibody; RAP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Alpha-2-macroglobulin receptor-associated protein (35-357AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
  • 基因功能參考文獻(xiàn)：
    1. The clinical and biometric features we describe in this report characterize LRPAP1-related high myopia and should raise suspicion for mutations in the gene. PMID: 26271838
    2. The inhibition caused by reagents that prevented the activation of Rap was reversed by mobilizing intracellular calcium pharmacologically, whereas that caused by acrosome reaction inhibitors that impeded Rab3's binding to GTP was not. PMID: 25159528
    3. The LRPAP1 I allelic variant may be considered a candidate gene for PD, predominantly in patients having the APOE epsilon4 allelic variant. PMID: 24504617
    4. RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells. PMID: 23894629
    5. Mutations in LRPAP1 are associated with severe myopia in humans. PMID: 23830514
    6. LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD. PMID: 20637261
    7. Findings reveal that RAP is a novel Abeta-binding protein that promotes cellular internalization of Abeta. PMID: 19826010
    8. Adenoviral-mediated expression of human receptor-asociated protein RAP in a murine model of von Willebrand disease results in a continuous rise in FVIII over 6 days. PMID: 11992244
    9. RAP is organized into three domains located in the first third (1D), middle third (2D), and last third (3D) of the protein; all three domains adopt stable tertiary structure as isolated domains and are monomers. PMID: 14674767
    10. NMR structure of domain 1 of receptor-associated protein PMID: 15213425
    11. An insertion allele is found to be associated with gallstone disease. PMID: 16704534
    12. RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo PMID: 17123336
    13. analysis of the relationship between ACE and LRPAP1 gene polymorphisms and age in an Italian population PMID: 17536759
    14. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. PMID: 17913606
    15. Low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism is associated with gallstone disease and gallbladder carcinoma PMID: 17987404
    16. LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells. PMID: 18055545
    17. alterations of the RAP gene are not a common cause of hypothyroidism PMID: 18075286
    18. Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias. PMID: 18721259

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  • 相關(guān)疾?。?/div>
    Myopia 23, autosomal recessive (MYP23)
  • 亞細(xì)胞定位：
    Rough endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment lumen. Golgi apparatus, cis-Golgi network. Golgi apparatus lumen. Endosome lumen. Cell surface.
  • 蛋白家族：
    Alpha-2-MRAP family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6701

    OMIM: 104225

    KEGG: hsa:4043

    STRING: 9606.ENSP00000421922

    UniGene: Hs.40966