Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAPRE2 Antibody

MAPRE2 Antibody

  • 中文名稱：
    MAPRE2兔多克隆抗體
  • 貨號：
    CSB-PA618987LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: MAPRE2 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 30, 36, 33, 31 kDa
      Observed band size: 38, 36 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA618987LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MAPRE2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MAPRE2
  • 別名：
    APC binding protein EB1 antibody; APC binding protein EB2 antibody; APC-binding protein EB2 antibody; EB1 antibody; EB2 antibody; End binding protein 2 antibody; End-binding protein 2 antibody; H.sapiens mRNA for novel T cell activation protein antibody; MAPRE2 antibody; MARE2_HUMAN antibody; Microtubule associated protein RP/EB family member 2 antibody; Microtubule-associated protein RP/EB family member 2 antibody; RP1 antibody; T cell activation protein EB1 family antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Microtubule-associated protein RP/EB family member 2 protein (159-240AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，MAPRE2 Antibody (CSB-PA618987LA01HU)，的標(biāo)記方式是Non-conjugated。對于MAPRE2 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA618987LB01HU MAPRE2 Antibody, HRP conjugated ELISA
    FITC CSB-PA618987LC01HU MAPRE2 Antibody, FITC conjugated
    Biotin CSB-PA618987LD01HU MAPRE2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
  • 基因功能參考文獻(xiàn)：
    1. Aurora B and CDK1 temporally regulate the binding affinity of EB2 for microtubules, thereby ensuring kinetochore microtubule dynamics, proper mitotic progression and genome stability. PMID: 27030108
    2. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. PMID: 26637975
    3. EB2 is evidently important for initial microtubule reorganisation during epithelial polarisation, whereas its downregulation facilitates EB1 and ACF7 microtubule lattice association, microtubule-actin filament co-alignment and bundle formation. PMID: 23813963
    4. results suggest that EB1 and ClipCG12 act cooperatively to regulate microtubule dynamics (EB1) PMID: 22424550
    5. heterodimer formation between EB1 and EB3, but not between EB2 and the other two EBs, occurs both in vitro and in cells as revealed by live cell imaging PMID: 20008324
    6. Data suggest that a functional interaction between EB1 and p150(Glued) is required for microtubule minus end anchoring at centrosomes during the assembly and maintenance of a radial microtubule array. PMID: 12388762
    7. EB1 may modulate kinetochore microtubule polymerization and/or attachment PMID: 12475954
    8. results support the novel hypothesis that EB1 overexpression may play a role in the development of esophageal squamous cell carcinoma by affecting APC function and activating the beta-catenin/TCF pathway PMID: 16007168
    9. Impaired EB1 or APC function generates lesions invisible to the spindle checkpoint and thereby promotes low levels of chromosomal loss (CIN) expected to fuel aneuploidy and possibly tumorigenesis. PMID: 16763565
    10. These data demonstrate that the COP9 signalosome-dependent protection of EB1 is important for microtubule function. PMID: 17350042
    11. Crystal structures of the tubulin binding domains of XMAP215 (yeast Stu2p and Drosophila Msps), EB1 (yeast Bim1p and human EB1), and CLIP-170 (human), which reveal diverse tubulin binding interfaces, are reported. PMID: 17889670
    12. p150Glued may activate and thereby facilitate the recruitment of EB1 to the tips of microtubules to regulate their dynamics. PMID: 18081319
    13. EB1-tubulin interactions are mediated in part by the same tubulin acidic tails utilized by other MAPs PMID: 19778897
    14. MAPRE2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion PMID: 19787265

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Skin creases, congenital symmetric circumferential, 2 (CSCSC2)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
  • 蛋白家族：
    MAPRE family
  • 組織特異性：
    Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6891

    OMIM: 605789

    KEGG: hsa:10982

    STRING: 9606.ENSP00000300249

    UniGene: Hs.532824