MC2R Antibody
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中文名稱:MC2R兔多克隆抗體
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貨號(hào):CSB-PA214837
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規(guī)格:¥1100
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:ACTH receptor antibody; ACTH-R antibody; ACTHR antibody; ACTHR_HUMAN antibody; Adrenocorticotropic hormone receptor antibody; Adrenocorticotropin receptor antibody; Corticotropin receptor antibody; MC2 receptor antibody; MC2-R antibody; MC2R antibody; Melanocortin 2 receptor (adrenocorticotropic hormone) antibody; Melanocortin 2 receptor antibody; Melanocortin receptor 2 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse
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免疫原:Synthetic peptide of Human MC2R
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:Antigen affinity purification
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB
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推薦稀釋比:
Application Recommended Dilution ELISA 1:2000-1:10000 WB 1:1000-1:5000 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
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基因功能參考文獻(xiàn):
- Results show regulation of melanocortin receptors MC2R, MC3R and MC4R gene expressions in CD8(+) cytotoxic T-lymphocytes and CD19(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha) inhibitor adalimumab. PMID: 28426141
- melanocortin receptors MC2R, MC3R and MC5R are most abundantly expressed in glandular epithelium of the endometrium PMID: 26223677
- the MC2R gene may contribute to the development of intracerebral hemorrhage. PMID: 26115626
- The A allele at rs1941088 in the MC2R gene, which encodes the adrenocorticotropic hormone (corticotropin, ACTH) receptor, is associated with a low cortisol response in critically ill children. PMID: 25055195
- results suggest that Phe(7) in ACTH plays an important role in ligand selectivity and that the third transmembrane domain of MC2R is crucial for ACTH selectivity and potency PMID: 25605722
- MC2R overexpression is associated with myelolipomas. PMID: 24884994
- The patient with familial glucocorticoid deficiency was found to be homozygous for a novel mutation in the melanocortin-2 receptor gene (635insC, I154H). PMID: 24224542
- Our observations suggest that MC2R is involved in prostate carcinogenesis and that targeting MC2R signaling may provide a novel avenue in prostate carcinoma treatment. PMID: 22842514
- The ACTHR gene -2T>C variant may be one important factor that influences stress perception of patients with alopecia areata. PMID: 23231661
- Significant differences in the gene expression of aldosterone synthase and adrenocorticotropic hormone receptor distinguishes adrenal neoplasms from primary aldosteronism. PMID: 23023242
- GRA5556G, GRA5556G, GAGG4534/4536AAAG polymorphisms and ACTHR promoter T-2C variants might be associated with quantitative trait of stress. PMID: 22357529
- No significant difference was found between plasma lipid and glucose levels and various GR and ACTHR genotypes. PMID: 22487832
- Intracellular Ser and Thr (S/T) residues of MC2R were found to play important roles not only in plasma membrane targeting and function but also in promoting receptor internalization. PMID: 21920850
- Familial glucocorticoid deficiency in five Arab kindreds with homozygous point mutations of the ACTH receptor (MC2R). PMID: 21778684
- The MC2R/MRAP2 complex requires much higher concentrations of ACTH to activate compared with the MC2R/MRAP complex. PMID: 21367968
- C-terminal tail of the MC(4) receptor with the corresponding regions from the MC(2) receptor resulted in MRAP-dependent signaling PMID: 21211532
- ACTH binding to MC2R stimulates PKA-dependent p44/p42(mapk) phosphorylation. PMID: 21195128
- MC2R expression is aberrant in alopecia areata (AA). A deficit in ACTH/MC2R activity may play an important role in the pathophysiology of AA. PMID: 20590821
- Loss of the C terminus of MC2R impairs cell surface expression and ACTH sensitivity but does not disrupt interaction of MC2R with melanocortin receptor accessory protein. PMID: 20962024
- Data show that tall stature is associated with mutations in MC2R but not in MRAP. PMID: 19558534
- Includes the study of a polymorphic upstream ORF in this gene, and shows that it functions to reduce protein levels by ~37%. PMID: 19372376
- The results showed that the haplotype TCCT in MC2R promoter significantly led to increased MC2R expression and strong responses to adrenocorticotropin hormone. PMID: 20042918
- Absence of MC2R N-glycosylation abrogates to a large extent MC2R cell surface expression in the absence of accessory proteins, whereas when MC2R is N-glycosylated, it can be expressed at the plasma membrane without assistance. PMID: 20022931
- No mutations in MC2R, MRAP or STAR were identified in any patient with Addison's disease PMID: 19903795
- findings suggest a novel mechanism is involved in the constitutive activation of the melanocortin 2 receptor in which failure of desensitization appears to be associated with enhanced basal receptor activity PMID: 12456795
- Cyclic AMP-induced regulation of transcriptional activity of gene achieved through two SF1 binding elements in proximal promoter. Regulation by angiotensin II by two AP1 binding sites. Region in promoter responsible for tissue-specific gene expression. PMID: 12530626
- ACTH feedback loop in pituitary. Loss of expression of ACTH-R in corticotroph adenomas in Cushing's disease may play role in resistance to feedback of pituitary-adrenal axis. PMID: 14671214
- Study of two mutations in the same allele of MC2R associated with clinical hypersensitivity to ACTH shows that each alone produces an inactive receptor, but together lead to a receptor with a highly significant elevation in constitutive activity PMID: 15062562
- Data show that an E-box is involved in the repression of melanocortin 2 receptor gene expression in granulosa cells through interactions with several factors. PMID: 15171714
- We describe an ACTH receptor promoter polymorphism that results in lower promoter activity in vitro and is associated with lower cortisol secretion to prolonged ACTH stimulation in vivo. Might influence cortisol homeostasis under stress conditions. PMID: 15240582
- DAX-1 is a major repressor of ACTH-R gene expression in vitro and in vivo. PMID: 15879363
- Specific factors, missing in cells which do not express any melanocortin receptor, are involved in the correct addressing of human MC2R to the cell membrane. PMID: 15982783
- Genetic variations within ACTH receptor promoter result in decreased DHEA secretion. We might have identified one of the genetic factors responsible for variation in ACTH-dependent DHEA secretion. PMID: 16260430
- PKA and protein kinase C act synergistically to induce hMC2R desensitization, but only PKA is essential for receptor internalization PMID: 16497811
- MC2R mutations were found in patients diagnosed with salt-losing forms of adrenal hypoplasia; these changes represent severely disruptive loss-of-function mutations including the first reported homozygous frameshift mutation PMID: 17223989
- MC2R-green fluorescent protein fusion transfected with either MRAPalpha or MRAPbeta was impaired both in cell membrane localization and signaling. PMID: 17456795
- Testicular adrenal rest tumors produce adrenal-specific steroids and express adrenal-specific enzymes and ACTH and AII receptors, confirming the strong resemblance with adrenal tissue. PMID: 17595257
- Transcription factors of the CREB/CREM/ATF family have a moderate effect on human MC2-R promoter activity, but seem to play a minor role in transmitting stimulation of the cAMP pathway to increased MC2-R expression. PMID: 17712720
- Results indicate that ACTH1-16 is the minimal peptide required for hMC2R binding and signaling. PMID: 17877367
- Corticotrophin-releasing hormone induces ACTHR receptor as potently as ACTH during late gestation. PMID: 17959886
- results do not support an involvement of the -2 CTC to CCC ACTH receptor promoter polymorphism in somatoform disorders PMID: 18197087
- The MC2R promoter polymorphism modulates the hypothalamo-pituitary-adrenal axis in children and may play a role in altered regulation of adrenarche. PMID: 18356748
- Significant differences in genotype frequency among ethnic groups studied were found for each of the six variants analyzed. the allele -184A with a protective effect from heroin addiction in Hispanics. PMID: 18359160
- two mutations of the ACTH receptor (MC2R) gene are reported in this familial glucocorticoid deficiency clinical case. PMID: 18492762
- In cortices attached to adrenocortical adenomas, MC2R mRNA was expressed faintly in zona fasciculata and zona reticularis. PMID: 18505908
- The transmembrane domain of MRAP is the MC2R interaction domain and a conserved N-terminal tyrosine-rich domain of MRAP is required for trafficking MC2R to the cell surface. PMID: 18818285
- The majority of MC2R mutations found in familial glucocorticoid deficiency type 1 fail to function because they fail to traffic to the cell surface PMID: 18840636
- MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal. PMID: 18981183
- The polymorphisms of the MC2R promoter might be one important factor that influences the efficacy of ACTH therapy on infantile spasms. PMID: 19024088
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相關(guān)疾?。?/div>Glucocorticoid deficiency 1 (GCCD1)亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.蛋白家族:G-protein coupled receptor 1 family組織特異性:Melanocytes and corticoadrenal tissue.數(shù)據(jù)庫(kù)鏈接:
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