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MCM3AP Antibody

  • 中文名稱(chēng)：
    MCM3AP兔多克隆抗體
  • 貨號(hào)：
    CSB-PA243490
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GANP antibody.
    • Western blot analysis of extracts from NIH/3T3 cells, using GANP antibody.
    • Western blot analysis of extracts from HepG2 cells (Lane 2) and A549 cells (Lane 3), using GANP antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) MCM3AP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCM3AP
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human GANP.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類(lèi)型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.; Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
  • 基因功能參考文獻(xiàn)：
    1. The identification of MCM3AP variants in affected individuals from multiple centres establishes it as a disease gene for childhood-onset recessively inherited Charcot-Marie-Tooth neuropathy with intellectual disability. PMID: 28633435
    2. MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child PMID: 26615982
    3. These results indicated that the GANP protein is associated with breast cancer resistance. PMID: 26749495
    4. GANP is induced in activated T4 cells & physically interacts with A3G. GANP is encapsidated in HIV-1 virions & modulates A3G packaging into the cores. Upregulation increases A3G-catalyzed viral G-->A hypermutation, suppressing infectivity. PMID: 24198285
    5. A homozygous potentially pathogenic variant (c.2743G>A) was identified, which encodes amino acid Lys, instead of conserved Glu, at the position 915, in patients with mild intellectual disability. PMID: 24123876
    6. GANP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AID targeting. PMID: 23652018
    7. The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus. PMID: 23094019
    8. HBV DNA integration sites into human genome were random, and MCM3AP was a new site. PMID: 20714864
    9. GANP, a homologue of yeast Sac3 that is involved in mRNA export, is indispensable for ensuring the stability of human genomic DNA and GANP knockdown causes apoptosis and necrosis of p53-insufficient cancer cells. PMID: 22395445
    10. GANP transgene may play a critical role in Lyn tyrosine-protein kinase-mediated signaling during selection of high-affinity B cells in peripheral lymphoid organs. PMID: 22942428
    11. MCM3AP and GANP are different proteins, occupying different locations in the cell and transcribed from different promoters PMID: 21195085
    12. Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export. PMID: 20384790
    13. GANP may serve as an essential link required to transport AID to B-cell nuclei and to target AID to actively transcribed IgV regions PMID: 20507984
    14. GANP depletion inhibits mRNA export, with retention of mRNPs and NXF1 in punctate foci within the nucleus. PMID: 20005110
    15. inhibits initiation of DNA replication via binding to MCM3 PMID: 12226073
    16. plays a certain important role in the maturation of immunoglobulin or selection of B cells in germinal centers during the immune response to TD-Ag. A selective function of GANP molecule on B cell proliferation and differentiation might exist. PMID: 12885157
    17. abnormal over-expression of GANP together with AID might be associated with rigorous DNA damage, potentially causing the malignant development of Cholangiocarcinoma (CCAs) during long-term inflammation. PMID: 19578742
    18. GANP protects cells from cellular senescence caused by DNA damage and that a significant decrease in GANP expression leads to malignancy by generating hyperploidy and chromosomal instability (CIN). PMID: 19686285

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  • 亞細(xì)胞定位：
    [Isoform GANP]: Nucleus envelope. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Chromosome.; [Isoform MCM3AP]: Cytoplasm. Nucleus.
  • 蛋白家族：
    SAC3 family
  • 組織特異性：
    Widely expressed. Up-regulated in germinal center B-cells in tonsils (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6946

    OMIM: 603294

    KEGG: hsa:8888

    STRING: 9606.ENSP00000291688

    UniGene: Hs.389037