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MOK Antibody

  • 中文名稱：
    MOK兔多克隆抗體
  • 貨號：
    CSB-PA105552
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HepG2 cells, COLO205 cells and 293 cells, using MOK antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using MOK antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MOK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MOK
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human MOK.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
  • 基因功能參考文獻：
    1. our results suggest MOK promoter hypomethylation is a common event and contributes to MOK overexpression in acute myeloid leukemia PMID: 25755699
    2. The findings indicate a statistically significant association of p.Gly82Ser polymorphism in RAGE with DR in T2DM patients. PMID: 24529564
    3. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    4. Our results suggest that RAGE may be important in tumor invasion and could be a potential predictor for the prognosis of hepatocellular carcinoma patients. PMID: 21717246
    5. PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups. PMID: 21377387
    6. The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B. PMID: 21264954
    7. RAGE was demonstrated in all 8 yolk sac tumors and 21 of 26 embryonal carcinomas. In yolk sac tumors, RAGE reactivity was diffusely present throughout the tumors. In embryonal carcinomas, RAGE was identified only in yolk sac components PMID: 12777992
    8. identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2 PMID: 15327990
    9. May provide suitable targets for immunotherapy of renal cell carcinoma. PMID: 15900605
    10. Compared RAGE and PAX-2 staining in metastatic clear renal cell carcinoma. PMID: 18685487
    11. POLL is under genetic selection in Sub-Saharan African populations. PMID: 19060005

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  • 亞細胞定位：
    Cytoplasm. Cell projection, cilium. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性：
    Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9833

    OMIM: 605762

    KEGG: hsa:5891

    STRING: 9606.ENSP00000355304

    UniGene: Hs.104119