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MTAP Antibody

  • 中文名稱:
    MTAP兔多克隆抗體
  • 貨號:
    CSB-PA622639LA01HU
  • 規(guī)格:
    ¥440
  • 促銷:
    小規(guī)格抗體限時一口價
  • 圖片:
    • Western Blot
      Positive WB detected in: NIH/3T3 whole cell lysate, Mouse liver tissue, Mouse kidney tissue
      All lanes: MTAP antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 32, 39, 37, 31, 34, 33, 27 kDa
      Observed band size: 32, 39 kDa
    • Immunofluorescent analysis of U251 cells using CSB-PA622639LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MTAP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MTAP
  • 別名:
    5' methylthioadenosine phosphorylase antibody; 5''-methylthioadenosine phosphorylase antibody; BDMF antibody; c86fus antibody; DMSFH antibody; DMSMFH antibody; Epididymis luminal protein 249 antibody; HEL 249 antibody; LGMBF antibody; MeSAdo phosphorylase antibody; Methylthioadenosine phosphorylase antibody; MSAP antibody; MTA phosphorylase antibody; MTAP antibody; MTAP_HUMAN antibody; MTAPase antibody; S methyl 5 thioadenosine phosphorylase antibody; S methyl 5' thioadenosine phosphorylase antibody; S-methyl-5''-thioadenosine phosphorylase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human S-methyl-5\'-thioadenosine phosphorylase protein (1-283AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,MTAP Antibody (CSB-PA622639LA01HU),的標(biāo)記方式是Non-conjugated。對于MTAP Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA622639LB01HU MTAP Antibody, HRP conjugated ELISA
    FITC CSB-PA622639LC01HU MTAP Antibody, FITC conjugated
    Biotin CSB-PA622639LD01HU MTAP Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:2000-1:10000
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
  • 基因功能參考文獻:
    1. melanoma risk alleles correlate with an allele-specific hyper-methylation and down-regulation of gene expression PMID: 27761950
    2. The obtained data suggested a negative association between copy number variation of the MEAP genes and Atherothrombotic stroke. PMID: 28477716
    3. High MTAP expression is associated with prostate cancer. PMID: 26910893
    4. Results indicate complex rearrangements involving CDKN2A locus and frequent occurrence of fusion transcripts involving methylthioadenosine phosphorylase (MTAP) and ANRIL genes. PMID: 26909863
    5. The SNP rs7023954 of methylthioadenosine phosphorylase co-dominantly expressed alleles revealed no difference in the conversion rate of 5'-methylthioadenosine to adenine and 5-methylthioribose-1-phosphate, indicating that this known enzymatic activity does not modulate the tumor suppressive function of methylthioadenosine phosphorylase. PMID: 27479139
    6. Data demonstrate that MTAP deficiency leads to accumulation of MTA inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver. PMID: 26819315
    7. methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. PMID: 27068473
    8. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors. PMID: 26751376
    9. study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors PMID: 26088413
    10. MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma PMID: 26656376
    11. In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1. PMID: 25426549
    12. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients. PMID: 24969958
    13. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB activation and apoptosis in hepatic stellate cells. PMID: 24324622
    14. SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD. PMID: 23462334
    15. Homozygous deletion of MTAP gene is associated with haploid lymphoblastic leukemia. PMID: 23508829
    16. Authors report here that a high percentage of t-cell lymphoma lack the enzyme methylthioadenosine phosphorylase (MTAP). PMID: 23040436
    17. MTAP gene might be involved in the etiology of myocardial infarction in Chinese Han ethnicity. PMID: 20302706
    18. Letter: inactivation of MTAP expression seems to be an important step in the development and progression of malignant melanoma. of PMID: 23000879
    19. Data indicate that a signature of seven biomarkers (Bax, Bcl-X, PTEN, COX-2, beta-Catenin, MTAP and CD20) was found to be an independent negative predictor for overall and recurrence-free survival in cutaneous malignant melanoma (MM). PMID: 22685558
    20. A large negative heat capacity change of -600 cal/(mol K) upon inhibitor binding to MTAP is consistent with altered hydrophobic interactions and release of water. PMID: 21985704
    21. Polymorphisms in nevus-associated genes MTAP is associated with invasive cutaneous melanoma. PMID: 21962134
    22. The present study suggests that MTAP plays an important role in the regulation of gastric carcinogenesis. PMID: 21412930
    23. Expression of MTAP is significantly higher in human colorectal cancer than in normal colorectal tissues. Demethylation of MTAP promoter may play an important role in up-regulating MTAP expression. PMID: 19622299
    24. The expression of MTAP protein in non-small cell lung cancer tissue was significantly lower than that in paracarcinomous tissue and borderline lung tissue. PMID: 21342647
    25. MTAP deficiency results in accumulation of 5'-deoxy-5'-methylthioadenosine, which is associated with increased tumorigenicity. PMID: 21356366
    26. CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)), and MTAP are abundantly expressed in atherosclerotic lesions. PMID: 20637465
    27. MTDIA antitumor activity in xenografts supports MTAP as a target for lung cancer therapy. PMID: 21135097
    28. Single nucleotide polymorphism in MTAP gene is associated with nevi. PMID: 20574843
    29. Detection of CDKN2A-MTAP co-deletion in peritoneal mesotheliomas can help identify those patients who may have an unfavorable outcome PMID: 20081810
    30. MTAP homozygous deletion, the predominant mechanism to deplete protein expression, is present in 17% of gastrointestinal stromal tumors PMID: 19887491
    31. Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line. PMID: 12438261
    32. Results suggest an important role of methylthioadenosine phosphorylase inactivation in the development of melanomas. PMID: 12875987
    33. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites PMID: 14506228
    34. MTAP is not expressed in normal human colonic epithelium but is strongly upregulated in colon carcinoma. PMID: 15492751
    35. epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma PMID: 15511635
    36. MTAP activity is frequently lost, and ODC activity is frequently elevated in both pancreatic adenocarcinoma and neuroendocrine tumors PMID: 15534104
    37. MTAP expression is lost in approximately 30% of infiltrating pancreatic cancers and in a lower percentage of other periampullary neoplasms; loss is a result of homozygous deletions encompassing both the MTAP and p16INK4A/CDKN2A genes PMID: 15662124
    38. Results demonstrated concordant loss of MTAP and p16 protein expression in pancreatic intraepithelial neoplasia. PMID: 15832197
    39. MTAP inactivation is associated with hepatocellular carcinoma development and invasiveness PMID: 16081515
    40. Selective loss at the 3' end of MTAP was observed in head and neck squamous cell carcinoma cell line UMSCC-11A. PMID: 16618910
    41. The frequency of Methylthioadenosine phosphorylase (MTAP) deletions in conventional, grade II chondrosarcomas by fluorescence in situ hybridization (FISH) analysis was investigated. PMID: 16631464
    42. Methylthioadenosine phosphorylase (MTAP) gene deletion and lack of protein expression are associated with poor prognosis in mantle cell lymphoma. PMID: 16778103
    43. Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver PMID: 18237276
    44. analysis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma PMID: 18555557
    45. This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of myocardial infarction in Chinese. PMID: 19272367
    46. The G allele of rs10118757 was associated with an increased risk of stroke in Han Chinese even after controlling for confounding factors. The GA+GG genotype was associated with the increased risk of an undetermined subtype of ischemic stroke. PMID: 19427650

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  • 相關(guān)疾?。?/div>
    Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    PNP/MTAP phosphorylase family, MTAP subfamily
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7413

    OMIM: 112250

    KEGG: hsa:4507

    STRING: 9606.ENSP00000369519

    UniGene: Hs.193268