Your Good Partner in Biology Research

MTMR9 Antibody

  • 中文名稱:
    MTMR9兔多克隆抗體
  • 貨號(hào):
    CSB-PA847211LA01HU
  • 規(guī)格:
    ¥440
  • 促銷:
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片:
    • Immunofluorescence staining of A549 cells with CSB-PA847211LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MTMR9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MTMR9
  • 別名:
    MTMR9 antibody; C8orf9 antibody; MTMR8 antibody; Myotubularin-related protein 9 antibody; Inactive phosphatidylinositol 3-phosphatase 9 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Myotubularin-related protein 9 protein (322-549AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,MTMR9 Antibody (CSB-PA847211LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于MTMR9 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA847211LB01HU MTMR9 Antibody, HRP conjugated ELISA
    FITC CSB-PA847211LC01HU MTMR9 Antibody, FITC conjugated
    Biotin CSB-PA847211LD01HU MTMR9 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity. Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine.
  • 基因功能參考文獻(xiàn):
    1. Polymorphism of rs2293855 in MTMR9 is associated with measures of glucose tolerance, indices of insulin secretion and indices of insulin sensitivity. PMID: 24937802
    2. MTMR6, which dephosphorylates PI(3)P to PI, and its binding partner MTMR9, are required for macropinocytosis. PMID: 24591580
    3. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome. PMID: 21796137
    4. Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. PMID: 17855449
    5. MTMR9 greatly enhances the functions of MTMR6 PMID: 19038970

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Endoplasmic reticulum.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 組織特異性:
    Expressed in many tissues.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 14596

    OMIM: 606260

    KEGG: hsa:66036

    STRING: 9606.ENSP00000221086

    UniGene: Hs.591395