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MXD4 Antibody

  • 中文名稱:
    MXD4兔多克隆抗體
  • 貨號(hào):
    CSB-PA257244
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MAD4 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MXD4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MXD4
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human MAD4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
  • 基因功能參考文獻(xiàn):
    1. The E3 ligase activity of c-IAP1 was not required for downregulation of Mad4 expression. PMID: 22895069
    2. regulation by a transcriptional repressor complex that contains Miz-1 and c-Myc PMID: 12418961
    3. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells. PMID: 15469726
    4. replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes PMID: 16167342
  • 亞細(xì)胞定位:
    Nucleus.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 13906

    KEGG: hsa:10608

    STRING: 9606.ENSP00000337889

    UniGene: Hs.655020