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MYBPH Antibody, HRP conjugated

  • 中文名稱：
    MYBPH兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA618765LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MYBPH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MYBPH
  • 別名：
    bHLHe38 antibody; H protein antibody; H-protein antibody; l-myc protein antibody; l-myc-1 proto-oncogene antibody; LMYC antibody; MyBP H antibody; MyBP-H antibody; Mybph antibody; MYBPH_HUMAN antibody; myc-related gene from lung cancer antibody; MYCL antibody; Myosin binding protein H antibody; Myosin binding protein, 86-KD antibody; Myosin-binding protein H antibody; Oncogene lmyc antibody; V-myc avian myelocytomatosis viral oncogene homolog 1, lung carcinoma derived antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Myosin-binding protein H protein (3-159AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
  • 基因功能參考文獻：
    1. variation in MYBPH can modulate the severity of hypertrophy in hypertrophic cardiomyopathy patients. PMID: 26969327
    2. MyBP-H expression signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of amyotrophic lateral sclerosis. PMID: 24184715
    3. These results suggest that MYBPH inhibits RLC and NMHC IIA, independent components of NM IIA, and negatively regulates actomyosin organization at 2 distinct steps, resulting in firm inhibition of NM IIA assembly. PMID: 23068101
    4. MYBPH inhibited assembly competence-conferring phosphorylation of the myosin regulatory light chain (RLC) as well as activating phosphorylation of LIM domain kinase, unexpectedly through its direct physical interaction with Rho kinase 1 PMID: 22085929
  • 蛋白家族：
    Immunoglobulin superfamily, MyBP family
  • 組織特異性：
    Mainly expressed in the skeletal muscle. Slightly expressed in the left atrium and arteria mammaria interna.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7552

    OMIM: 160795

    KEGG: hsa:4608

    STRING: 9606.ENSP00000255416

    UniGene: Hs.927