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MYOM1 Antibody

  • 中文名稱(chēng)：
    MYOM1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA015361GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MYOM1
  • 別名：
    190 kDa connectin-associated protein antibody; 190 kDa titin-associated protein antibody; EH myomesin antibody; MGC134946 antibody; MGC134947 antibody; MYOM1 antibody; MYOM1_HUMAN antibody; Myomesin (M protein) 1 (190kD) antibody; Myomesin 1 (skelemin) 185kDa antibody; Myomesin 1 185kDa antibody; Myomesin 1, 185kDa antibody; Myomesin family member 1 antibody; Myomesin-1 antibody; Skelemin antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MYOM1-Specific
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
  • 基因功能參考文獻(xiàn)：
    1. Crystal structure of the obscurin(-like-1):myomesin complex reveals a trans-complementation mechanism whereby an incomplete immunoglobulin-like domain assimilates an isoform-specific myomesin interdomain sequence. PMID: 27989621
    2. individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF-1 splice forms in cultured myoblasts PMID: 25152160
    3. myomesin could act as a highly elastic ribbon to maintain the overall structural organization of the sarcomeric M-band. PMID: 22347812
    4. Our results suggest that the downregulation of MBNL proteins should lead to the abnormal splicing of MYOM1 exon 17a in DM1 muscle. PMID: 21794030
    5. EH-myomesin levels were up-regulated at least 10 times in dilated cardiomyopathy patients compared to controls. PMID: 21069531
    6. This missense mutation caused significant changes of biochemical and biophysical properties of myomesin fragments indicating a role in the pathogenesis of hypertrophic cardiomyopathy . PMID: 21256114
    7. Results identify muscle-type creatine kinase as a binding partner of a central portion of myomesin and the closely related M-protein. PMID: 12972258
    8. visco-elastic properties of myomesin might be crucial for the stability of the sarcomere PMID: 15890201

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  • 亞細(xì)胞定位：
    Cytoplasm, myofibril, sarcomere, M line.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 7613

    OMIM: 603508

    KEGG: hsa:8736

    STRING: 9606.ENSP00000348821

    UniGene: Hs.464469