NIT1 Antibody
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中文名稱:NIT1兔多克隆抗體
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貨號:CSB-PA570196
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規(guī)格:¥1100
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圖片:
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA570196(NIT1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA570196(NIT1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, Human fetal liver tissue, Primary antibody: CSB-PA570196(NIT1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:NIT1
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別名:MGC57670 antibody; NIT1 antibody; NIT1_HUMAN antibody; Nitrilase 1 antibody; Nitrilase homolog 1 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Fusion protein of Human NIT1
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:Antigen affinity purification
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB,IHC
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推薦稀釋比:
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:200-1:1000 IHC 1:50-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.
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基因功能參考文獻:
- Data show that cisplatin response was enhanced in human lung cancer cells when Nit1 was knocked down and mice Nit1-/-:KrasG12D/+ tumors showed increased sensitivity to cisplatin in vivo. PMID: 26967383
- Human NIT1/2 are not involved in the metabolism of vildagliptin. PMID: 25008847
- Nit1 and Fhit share tumor suppressor signaling pathways, while localization of the NIT1 gene at a stable chromosome site explains the paucity of gene alterations and in frequent loss of expression of the NIT1 gene in human malignancies. PMID: 16864578
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亞細胞定位:[Isoform 2]: Mitochondrion.; [Isoform 1]: Cytoplasm.
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蛋白家族:Carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family
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組織特異性:Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
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數(shù)據(jù)庫鏈接:
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