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NKRF Antibody

  • 中文名稱：
    NKRF兔多克隆抗體
  • 貨號：
    CSB-PA015836GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NKRF
  • 別名：
    NKRF antibody; ITBA4 antibody; NRF antibody; NF-kappa-B-repressing factor antibody; NFkB-repressing factor antibody; Protein ITBA4 antibody; Transcription factor NRF antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human NKRF
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
  • 基因功能參考文獻(xiàn)：
    1. NKRF is a nucleolar HSP essential for nucleolus homeostasis and cell survival under proteotoxic stress. NKRF is a thermosensor translocating from the nucleolus to the nucleoplasm during heat stress; nucleolar pools are replenished upon HSF1-mediated NKRF resynthesis. NKRF is an unconventional HSP crucial for correct rRNA processing. Under stress conditions, NKRF directs XRN2 nucleolus/nucleoplasm trafficking. PMID: 28096332
    2. Data suggest that L protein from LCMV interactions with host proteome, specifically DDX3X, NKRF, and TRIM21. (LCMV = Lymphocytic choriomeningitis mammarenavirus; DDX3X = DEAD-box helicase 3; NKRF = NF-kappa-B-repressing factor; TRIM21 = tripartite motif-containing protein-21) PMID: 29261807
    3. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
    4. NF-kappaB-repressing factor (NKRF) phosphorylation modulates promoter-proximal transcription elongation of NF-kappaB/NKRF-regulated genes via direct interactions with elongation complex in response to specific stimuli PMID: 26340924
    5. The up-regulated NKRF serves as an endogenous repressor for IP-10 and IL-8 synthesis to hinder host from robust response to MTb infection. PMID: 25135111
    6. MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease. PMID: 25277410
    7. NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 and IL-8/CXCL8 when TB bacterial load is high. PMID: 24223729
    8. The expression of NKRF is decreased in PBMCs of patients with stable COPD. The downregulation of NKRF was found to be closely related to enhanced IL-8 production from these peripheral blood cells through de-repression of the IL-8 promoter. PMID: 22441735
    9. The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs. PMID: 21300069
    10. role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene PMID: 12381793
    11. cDNA is 3247 bp long, contains three exons and maps to human chromosome Xq24. NRF is widely expressed in human tissues. PMID: 14744032
    12. Full-length NRF is highly enriched in nucleoli and only a small fraction of NRF is found in the nucleoplasm and cytoplasm PMID: 15226370
    13. NRF interrupts the regulatory coupling of LTR binding factors and transcription elongation events; this inhibitory mechanism might contribute to transcriptional quiescence of integrated HIV-1 provirus PMID: 16107696
    14. Induction of MMP-9 gene expression is regulated by oscillatory/cumulative activation of NFkappaB in a colon cancer cell line. PMID: 17186550
    15. The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity. PMID: 17592041
    16. saimiri transformation-associated protein of subgroup C induces NF-kappaB activation PMID: 18560378
    17. Induction of NRF in human airway smooth muscle cells by neutrophil elastase mediates the suppression of interleukin (IL)-8/CXCL8 expression. PMID: 19542452

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  • 亞細(xì)胞定位：
    Nucleus, nucleolus.
  • 組織特異性：
    Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19374

    OMIM: 300440

    KEGG: hsa:55922

    STRING: 9606.ENSP00000442308

    UniGene: Hs.437084