NPSR1 Antibody
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中文名稱:NPSR1兔多克隆抗體
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貨號(hào):CSB-PA757818LA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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Western Blot
Positive WB detected in: Rat heart tissue, Mouse heart tissue, Mouse brain tissue
All lanes: NPSR1 antibody at 4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 43, 36, 45, 44, 42, 19, 16, 17, 11 kDa
Observed band size: 43 kDa -
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA757818LA01HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA757818LA01HU at dilution of 1:100
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) NPSR1 Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:NPSR1; GPR154; GPRA; PGR14; Neuropeptide S receptor; G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility
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宿主:Rabbit
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反應(yīng)種屬:Human, Mouse, Rat
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免疫原:Recombinant Human Neuropeptide S receptor protein (1-52AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
本頁(yè)面中的產(chǎn)品,NPSR1 Antibody (CSB-PA757818LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于NPSR1 Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, WB, IHC
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.
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基因功能參考文獻(xiàn):
- A decreased risk of psychological stress was only found in TT of NPSR1 (rs324981): A allele carriers vs. TT genotype (OR 1.64, 95% CI 1.11, 2.42), and AT genotype vs. TT genotype (OR 1.76, 95% CI 1.17, 2.65). We found that the NPSR1 (rs324981) T/T genotype decreased the risk of psychological stress, while the overall coping style was a risk factor for psychological stress. PMID: 30242809
- Results show higher fronto-limbic connectivity in adolescent A allele carriers vs. children carrying the A allele, a pattern which could not be discerned in TT homozygotes. Adolescent NPSR1 TT risk genotype carriers vs. adolescent A allele carriers displayed a reduced fronto-amygdala and fronto-insula effective connectivity suggesting basis of risk-increasing effect of the NPSR1T allele for anxiety. PMID: 26503268
- Sequence variation in NPSR1 may contribute to sex differences in stress regulation. PMID: 27883964
- we have utilized a broad-scaled affinity proteomics approach to identify three proteins (CCL5, HPGDS, and NPSR1) with altered plasma levels in asthmatic children compared to healthy controls, representing the first evaluation of HPGDS and NPSR1 in plasma. PMID: 27145233
- The interaction between 5-HTT (LL) and BDNF (A+) increased the risk of anxiety, and the interaction between BDNF (A+, GG) and NPSR1 (AA, T+) increased the risk of depression in asthmatic patients. PMID: 27176146
- findings demonstrate that hNPS-(1-10) is a biased agonist favoring Galphaq-dependent signaling. It may represent a valuable chemical probe for further investigation of the therapeutic potential of human NPS receptor-directed signalingin vivo. PMID: 26865629
- anxiety sensitivity correlated negatively with prefrontal activity in NPSR1 rs324981 carriers possibly suggesting a decompensation of the adaptive compensatory upregulation PMID: 25971599
- Results suggest the functional NPSR1 gene A/T variant to influence glutamate+glutamine concentrations in the bilateral anterior cingulate cortex in healthy male subjects during CCK-4 induced panic PMID: 26235955
- The T-allele of the NPSR1 rs324981 polymorphism is associated with increased impulsivity and ADHD-related traits in non-clinical cohorts. PMID: 25744621
- The results suggest neuropeptide S receptor gene variation to be associated with alterations of prefrontal functioning in the attentional functions alerting and executive control partly modulated by anxiety sensitivity. PMID: 25842293
- Results show that NPSR1 polymorphism is associated with AUD and alcohol consumption, dependent on sex, environment and age. PMID: 24754478
- gene polymorphism is a risk factor for high IgE-associated atopic eczema at the age of two years in Finland if there is no probiotic treatment PMID: 24439655
- The functional SNP rs324981 located in the gene of NPSR1 was significantly associated with objectively obtained sleep parameters in a sample of elderly white subjects PMID: 24896296
- results suggest a potential protective function of the NPSR1 rs324981 A/A genotype against pathologically enhanced anxiety that might be explained by stronger reflective prefrontal regulation over the subcortical fear response. PMID: 23103692
- Genetic variation at the NPSR1 locus impacts children's predisposition to ecurrent abdominal pain episodes in a Swedish population. PMID: 25091462
- study provides first evidence for the assumption that a NPSR1 variant modulates brain activation under stress, interacting with the environmental risk factor urban upbringing PMID: 24800784
- In the Estonian population, NPSR1 A/T polymorphism together with environmental factors is associated with anxious, depressive and activity-related traits, increased prevalence of affective/anxiety disorders and a higher likelihood of suicidal behaviour. PMID: 24331455
- NPSR1 A/T polymorphism is associated with impulsivity, ADHD symptoms and personality, mirroring the activity- and anxiety-mediating role of NPSR1. PMID: 23325374
- Neuropeptide S receptor 1 (NPSR1) activates cancer-related pathways and is widely expressed in neuroendocrine tumors. PMID: 24915894
- Differential gene-environment effects of the NPSR rs324981 T allele indicate recent life events with respect to anxiety sensitivity. PMID: 22404660
- NPS receptor may have a pathological role in individuals with severe asthma and/or elevated serum IgE levels. PMID: 24239856
- The present data demonstrated that QA1 and PI1 act as potent NPSR antagonists in vitro, however their usefulness for in vivo investigations in mice seems limited probably by pharmacokinetic reasons. PMID: 23911665
- Relate NPSR1 genotype to early onset obsessive-compulsive disorder. PMID: 23680103
- The results of this study showed involvement of the NPS system in the regulation of the neuroendocrine stress response in humans. PMID: 23466585
- RORA SNPs are associated with childhood asthma and show epistasis with NPSR1, and the interaction between RORA and NPSR1 may be of biological relevance. PMID: 23565190
- In summary, the more active NPSR1 T allele may confer enhanced response inhibition and increased error monitoring and might drive particularly error monitoring as a neurophysiological endophenotype of anxiety PMID: 23319044
- NPS is able to stimulate human monocyte chemotaxis and that this effect is entirely due to selective NPSR activation. PMID: 23142110
- DNA methylation levels in the promoter of NPSR1 showed small but significant associations with asthma and to related traits such as allergy and certain environmental exposures. PMID: 23372674
- we consider NPSR as a promising target for antipsychotic drug development PMID: 22078257
- analysis of molecular evolution of the neuropeptide S receptor and cross-species comparison PMID: 22479518
- NPSR1 gene is associated with reduced risk of rheumatoid arthritis. PMID: 22548958
- findings represent a first step to decipher NPSR1 locus complexity and its impact on several human conditions NPS antagonists have been recently described, and our results are of potential pharmacogenetic relevance PMID: 22216302
- Ther neuropeptide S receptor genotype is associated with increased amygdala responsiveness to fear-relevant stimuli. PMID: 21525857
- results provide converging evidence for a female-dominant role of NPSR gene variation in panic disorder through heightened autonomic arousal and distorted processing of anxiety-relevant emotional stimuli. PMID: 20603625
- There is an NPSR1 isoform-specific link to pathogenetic processes in asthma and allergy. PMID: 21707994
- data suggest a genetic and neuroanatomical substrate for catastrophizing overinterpretations of fear reactions. PMID: 20628342
- The available information regarding NPS and its receptor and the biological actions modulated by the NPS-NPSR system, is summarized. PMID: 19824051
- NPS-NPSR1 signaling is likely involved in anxiety PMID: 20705147
- Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20701904
- Data show that NPSR1 polymorphism may be relevant to RA susceptibility and its clinical manifestation. PMID: 20179762
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20603625
- Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20628342
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20705147
- Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20503287
- Results suggest that N-linked glycosylation is not important for neuropeptide S receptor biogenesis or function, and that residue D105 might be critical for receptor binding. PMID: 19874863
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20179762
- Expression of several neuropeptides is induced upon NPS-NPSR1 signaling; NPSR1 variants are associated with colonic transit in functional gastrointestinal diseases PMID: 19732772
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相關(guān)疾?。?/div>Asthma-related traits 2 (ASRT2)亞細(xì)胞定位:[Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 3]: Cell membrane; Multi-pass membrane protein.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 7]: Cytoplasm.; [Isoform 9]: Cytoplasm.蛋白家族:G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily組織特異性:Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle ce數(shù)據(jù)庫(kù)鏈接:
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