NRP2 Antibody
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中文名稱:NRP2兔多克隆抗體
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貨號:CSB-PA016092LA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA016092LA01HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA016092LA01HU at dilution of 1:100
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Immunofluorescent analysis of HepG2 cells using CSB-PA016092LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) NRP2 Polyclonal antibody
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Uniprot No.:
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基因名:NRP2
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別名:MGC126574 antibody; Neuropilin 2 antibody; Neuropilin-2 antibody; Neuropilin2 antibody; NP 2 antibody; NP2 antibody; NPN 2 antibody; NPN2 antibody; NRP 2 antibody; Nrp2 antibody; NRP2_HUMAN antibody; PRO2714 antibody; Receptor for VEGF165 and semaphorins class3 antibody; Vascular endothelial cell growth factor 165 receptor 2 antibody; Vascular endothelial growth factor 165 receptor 2 antibody; VEGF1265R2 antibody; VEGF165R2 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Neuropilin-2 protein (60-209AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
本頁面中的產(chǎn)品,NRP2 Antibody (CSB-PA016092LA01HU),的標(biāo)記方式是Non-conjugated。對于NRP2 Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC, IF
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.; (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
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基因功能參考文獻(xiàn):
- Overexpression of NRP2 is associated with spitzoid melanocytic lesions. PMID: 29227334
- The results of this study showed that there is a significant association betweenNPR2 rs849563 polymorphism and autism in the studied population PMID: 28484884
- The authors also identified single-nucleotide polymorphisms in NRP2 and IGFBP4 loci that increase and reduce risk of lichen planus in hepatitis C virus-infected patients, respectively. PMID: 28065765
- Authors found that NRP2 gene silencing in metastatic melanoma cell lines inhibited tumor cell growth in vitro; furthermore, knockdown of NRP2 expression in the metastatic melanoma cell line 1205Lu significantly inhibited in-vivo tumor growth and metastasis. PMID: 26881875
- Study identifies NRP2 and ESL-1 as targets for polysialylation in murine microglia and human THP-1 macrophages and reveals a striking convergence in the regulation of the two polysialylated acceptors in the course of inflammatory activation. A pool of polysialylated NRP2 and ESL-1 is assembled after injury or in culture and its shedding is an early response to lipopolysaccharide-induced activation of microglia. PMID: 27159043
- Neuropilin 2 isoform NRP2b contributed to the oncogenic response to transforming growth factor-beta (TGFbeta) and correlated with tumor progression in non-small cell lung cancer (NSCLC) patients. PMID: 28096505
- Sema3a-Nrp2 signaling along an unrecognized pancreatic developmental axis constitutes a chemoattractant system essential for generating the hallmark morphogenetic properties of pancreatic islets. PMID: 28893946
- NRP2 promotes tumourigenesis and metastasis in Oesophageal squamous cell carcinoma (ESCC) through deregulation of ERK-MAPK-ETV4-MMP-E-cadherin signalling. PMID: 27063000
- NRP2 inhibits WDFY1 transcription by preventing the nuclear localization of a transcription factor, Fetal ALZ50-reactive clone 1 (FAC1). PMID: 27026195
- SEMA3F-NRP2 interactions inhibit intracellular PI-3K activity, mTORC2-dependent signaling, RhoA activity and cytoskeletal stress fiber formation. PMID: 26156437
- NRP2/WDFY1 axis is required for maintaining endocytic activity in cancer cells, which supports their oncogenic activities and confers drug resistance. PMID: 26560516
- Data show significant increases in semaphorin3C, 3D and their receptor neuropilin-2 in degenerate samples which were shown to contain nerves and blood vessels, compared to non-degenerate samples without nerves and blood vessels. PMID: 26286962
- Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma PMID: 25890345
- Data indicate that semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) are expressed in the thymus. PMID: 25068647
- This is the first report of a targeted MRI molecular probe based on USPIO and VEGF165-aptamer. PMID: 24729581
- This preliminary study strongly supports the significance of NRP2 as a useful biomarker for malignant progression of melanoma, which may be useful for early identification of patients with melanoma at high risk. PMID: 24359286
- Data show that the transmembrane (TM)domains of neuropilins 1 and 2 dimerize with themselves. PMID: 25315821
- High NRP2 expression is associated with bladder cancer. PMID: 24862180
- Paxillin knockdown increases capillary endothelial cell migration and invasiveness, and thereby enhances microvessel ingrowth, by suppressing NRP2 expression. PMID: 24522185
- GATA2 and Lmo2 cooperatively regulate VEGF-induced angiogenesis and lymphangiogenesis via NRP2. PMID: 23892628
- Dysregulated expression of NRP-2 likely contributes to altered angiogenesis, lymphangiogenesis, neurogenesis and immune function in endometriosis. PMID: 23585340
- NRP2 contributes significantly to TGF-beta1-induced epithelial-mesenchymal transition in lung cancer. PMID: 24121493
- An increase in NRP1 and NRP2 epithelial/tumour expression, as well as in NRP1 vascular expression, may be associated with disease progression in colorectal cancer. PMID: 23551578
- GLI1 regulates the neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation. PMID: 23436775
- Neuropilin 2 enables the function of specific integrins that contribute to tumor initiation and progression. [review] PMID: 23076131
- NRP2 and VEGFR-3 mRNA levels were significantly higher in some of the vascular malformations endothelial cells. PMID: 22961441
- In the majority of lung, breast and colorectal cancers, the effects of anti-neuropilin-2 are likely to be restricted to the vasculature PMID: 22384800
- Inhibition of VEGF by EGCG was associated with suppression of neuropilin-2. PMID: 22971992
- the VEGF receptor NRP2 is induced by PTEN loss and VEGF/NRP2 signaling regulates the expression of Bmi-1, a key effector of prostate tumorigenesis induced by PTEN deletion PMID: 22777769
- In tumoral tissue, consistently strong staining of Neuropilin-2 was noted only in renal cell carcinoma but not in any of the other tumors studied. PMID: 21840568
- tumor cell-derived NRP-2 mediates critical survival signaling in gastrointestinal cancer cells PMID: 22028766
- Nrp2 expression was correlated with lymph node metastasis and VEGF-D expression in papillary thyroid carcinoma. Our data also showed a role for Nrp2 in regulating VEGF-D-induced invasion and migration in vitro. PMID: 21880798
- a direct role of NRP2 in epithelial-mesenchymal transition and highlight a cross-talk between neuropilin-2 and TGF-beta1 signaling to promote cancer progression PMID: 21747928
- dendritic cells express the NRP2 isoforms NRP2a and NRP2b, both are susceptible to polysialylation which is required to specifically enhance chemotaxis toward CCL21 PMID: 21199821
- A critical role of NRP2 in coordinated cell patterning and growth was confirmed using the coculture system. We conclude that NRP2 represents an important mediator of melanoma-endothelial interactions. PMID: 21324919
- Expression of Nrp2 protein is significantly correlated with tumor progression and angiogenesis in salivary adenoid cystic carcinomas. PMID: 20851535
- Mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression. PMID: 20651020
- Polysialyted NRP2 enhances dendritic cell migration through the basic c-terminal region of CCL21. PMID: 20488940
- BMSCs transfected with reconstructed plasmid pIRES-hBMP-2-VEGF165 could secret a high level of BMP-2 and hVEGF165. PMID: 20548225
- NRP2 is necessary to trigger Sema3A-induced glioma cell repulsion and attraction. PMID: 19855168
- human glioma cells express class 3 semaphorins and receptors for soluble and membrane-bound semaphorins, suggesting a possible role of the semaphorin/neuropilin system in the interactions of human malignant glioma with the nervous and immune systems. PMID: 12730958
- Np-1 and Np-2 contribute to autocrine-paracrine interactions in pancreatic cancer PMID: 14760080
- NP-2 mRNA, in endothelium, was expressed only by the endothelium of veins, and in these cells, its expression was hormonally regulated in the converse manner: it was very low during the proliferative phase and high during the secretory phase PMID: 15613413
- NRP2 acts as a coreceptor that enhances human endothelial cell biological responses induced by VEGF-A and VEGF-C. PMID: 16621967
- NP2 is directly involved in an active signaling complex with the key regulators of lymphangiogenesis. PMID: 16816121
- These results suggest that the expression of VEGFRs and NRPs on keratinocytes may constitute important regulators for its activity and may possibly be responsible for the autocrine signaling in the epidermis. PMID: 17088944
- The polymorphisms in the NRP2 gene are associated with autism, implying that the NRP2 gene may render individuals to be predisposed to autism. PMID: 17427189
- that neuropilin-2 (NRP-2), a receptor for the semaphorin and vascular endothelial growth factor families in neurons and endothelial cells, respectively, is expressed on the surface of human dendritic cells and is polysialylated. PMID: 17699524
- neoplastic cells in myeloid leukemias frequently express VEGFR including NRP-1 and NRP-2 PMID: 17917967
- Both NRP1 and NRP2 function as proangiogenic coreceptors, potentiating the activity of at least 2 proangiogenic cytokines, VEGF-A and hepatocyte grwoth factor. PMID: 18065694
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亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.; [Isoform s9]: Secreted.
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蛋白家族:Neuropilin family
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