NUP107 Antibody
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中文名稱:NUP107兔多克隆抗體
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貨號:CSB-PA016188GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:NUP107
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別名:107 kDa nucleoporin antibody; NU107_HUMAN antibody; Nuclear pore complex protein Nup107 antibody; Nucleoporin 107kDa antibody; Nucleoporin Nup107 antibody; NUP107 antibody; NUP84 antibody; NUP84; yeast; homolog of antibody; OTTHUMP00000240604 antibody; OTTHUMP00000240606 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Human NUP107
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.
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基因功能參考文獻(xiàn):
- Whole exome sequencing identified a novel and rare missense variant in the NUP107 gene (c.1063C>T, p.R355C) in both sisters with HH. PMID: 29363275
- NUP107 was suggested as a candidate in a family with nephrotic syndrome and developmental delay. PMID: 28280135
- Associations between biallelic NUP107 mutations and age at onset in children with steroid-resistant nephrotic syndrome. PMID: 27190346
- a variant in the 3'-UTR region Nup107 unique to sensitivity to platinum in ovarian cancer, was identified. PMID: 28562428
- Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines. PMID: 25904327
- a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N). This mutation segregated with the XX-GD phenotype and was not present in available databases or in 150 healthy ethnically matched controls. PMID: 26485283
- The central domain of Nup107 interfered with Apaf-1 nuclear translocation upon genotoxic stress, resulting in a marked reduction of Chk-1 activation and cell cycle arrest. PMID: 25695197
- Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. PMID: 26411495
- The functions have been ascribed to the NUP107 complex, ranging from Nuclear Pore Complex (NPC) assembly to mRNA export to cell differentiation. PMID: 22713280
- Study shows that 32 copies of the Nup107 subcomplex assemble into two reticulated rings, one each at the cytoplasmic and nuclear face of the nuclear pore complex. PMID: 24315095
- The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. PMID: 22031293
- did a Trypan Blue cell viability assay and it showed increased cell death in NUP107 transfected cells than untreated control PMID: 20490895
- These findings support the notion that Nup107 may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules. PMID: 20833136
- A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere. PMID: 19864462
- Data show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton. PMID: 20081840
- Nup107 functions as a keystone Nup that is required for the assembly of a subset of Nups into the nuclear pore complex PMID: 12552102
- Nup107-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores. PMID: 16807356
- phosphorylation does not affect interactions within the Nup107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins PMID: 17360435
- These data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores. PMID: 17363900
- When complexed with NUP133, this complex will give the first insights into the protein-protein interactions within a core module of the nuclear pore complex. PMID: 17768364
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相關(guān)疾病:Nephrotic syndrome 11 (NPHS11)
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亞細(xì)胞定位:Nucleus membrane. Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore.
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蛋白家族:Nucleoporin Nup84/Nup107 family
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組織特異性:Ubiquitously expressed in fetal and adult tissues.
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