ORC6 Antibody
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中文名稱:ORC6兔多克隆抗體
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貨號:CSB-PA893418ESR2HU
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規(guī)格:¥440
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促銷:
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圖片:
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Western blot
All lanes: ORC6 antibody at 16μg/ml
Lane 1: Mouse spleen tissue
Lane 2: MCF-7 whole cell lysate
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28 kDa
Observed band size: 28 kDa -
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA893418ESR2HU at dilution of 1:100
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) ORC6 Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:ORC 6 antibody; Orc6 antibody; ORC6_HUMAN antibody; ORC6L antibody; Origin recognition complex subunit 6 antibody; origin recognition complex subunit 6 homolog like antibody; origin recognition complex subunit 6 homolog like (yeast) antibody; origin recognition complex subunit 6 like (yeast) antibody
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宿主:Rabbit
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反應種屬:Human, Mouse
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免疫原:Recombinant Human Origin recognition complex subunit 6 protein (1-252AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:Antigen Affinity Purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式:Liquid
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應用范圍:ELISA, WB, IHC
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關產(chǎn)品
靶點詳情
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功能:Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
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基因功能參考文獻:
- The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene. PMID: 28186598
- The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation. PMID: 25691413
- our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions PMID: 24137536
- findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process. PMID: 21461783
- Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. PMID: 21502537
- results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis PMID: 12169736
- Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. PMID: 15910003
- Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin PMID: 19112505
- In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans. PMID: 19541634
- Functional studies of the Drosophila homolog PMID: 11593009
- Functional studies of the yeast homolog PMID: 8266075
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相關疾?。?/div>Meier-Gorlin syndrome 3 (MGORS3)亞細胞定位:Nucleus.蛋白家族:ORC6 family數(shù)據(jù)庫鏈接:
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