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PAOX Antibody

  • 中文名稱：
    PAOX兔多克隆抗體
  • 貨號(hào)：
    CSB-PA004746
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot analysis of rat stomach K562 cells using PAOX Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PAOX
  • 別名：
    PAOX antibody; PAO antibody; UNQ1923/PRO4398Peroxisomal N(1)-acetyl-spermine/spermidine oxidase antibody; EC 1.5.3.13 antibody; Polyamine oxidase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PAOX.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
  • 基因功能參考文獻(xiàn)：
    1. copy number gain in the polyamine oxidase (PAOX) gene locus was accompanied by a coordinated transcriptional up-regulation in Primary myelofibrosis patients PMID: 26547506
    2. PAO activity in children with type 1 diabetes mellitus was very high; higher blood HbA(1C) and MDA levels confirm the presence of oxidant stress demonstrate that PAO activity may participate in these circumstances PMID: 20405312
    3. polyamine oxidase degrades alpha-methylpolyamines in a stereospecific manner PMID: 16354669
  • 亞細(xì)胞定位：
    Peroxisome. Cytoplasm.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 組織特異性：
    Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20837

    OMIM: 615853

    KEGG: hsa:196743

    STRING: 9606.ENSP00000278060

    UniGene: Hs.501578