PDHX Antibody
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中文名稱:PDHX兔多克隆抗體
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貨號:CSB-PA017718ESR2HU
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規(guī)格:¥440
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促銷:
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圖片:
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Western blot
All lanes: PDHX antibody at 6μg/ml
Lane 1: 293T whole cell lysate
Lane 2: PC-3 whole cell lysate
Lane 3: MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55, 30, 52 kDa
Observed band size: 55 kDa -
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA017718ESR2HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017718ESR2HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA017718ESR2HU at dilution of 1:100
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) PDHX Polyclonal antibody
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Uniprot No.:
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基因名:PDHX
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別名:Dihydrolipoamide dehydrogenase binding protein of pyruvate dehydrogenase complex antibody; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex antibody; DLDBP antibody; E3 binding protein antibody; E3-binding protein antibody; E3BP antibody; Lipoyl containing pyruvate dehydrogenase complex component X antibody; Lipoyl-containing pyruvate dehydrogenase complex component X antibody; mitochondrial antibody; ODPX_HUMAN antibody; OPDX antibody; PDHX antibody; PDX 1 antibody; PDX1 antibody; Pro X antibody; proX antibody; Pyruvate dehydrogenase complex component X antibody; Pyruvate dehydrogenase complex lipoyl containing component X antibody; Pyruvate dehydrogenase complex; E3 binding protein subunit antibody; Pyruvate dehydrogenase protein X component antibody; Pyruvate dehydrogenase protein X component mitochondrial antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Pyruvate dehydrogenase protein X component, mitochondrial protein (1-300AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:Antigen Affinity Purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, WB, IHC
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
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基因功能參考文獻:
- We propose testing for the R446* mutation in PDHX as a rapid first screening in Roma infants with metabolic acidosis. PMID: 25087164
- MiR-26a regulates glucose metabolism of colorectal cancer cells by direct targeting PDHX. PMID: 24935220
- New mutation in PDHX gene found in two unrelated patients with Pyruvate dehydrogenase deficiency. PMID: 22766002
- genetic association with systemic lupus erythematosus to a haplotype between PDHX and CD44 was established. PMID: 21194677
- determination that PDH and complex III exist at a steady-state ratio of 1:100, 1:128 and 1:202 in HeLa cell extracts, fibroblast mitochondria and heart tissue mitochondria, respectively PMID: 12372595
- model of the pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and binding of the E1 and E3 components PMID: 14638692
- specificity of pairing for human E3BP with E3 from its subcomplex structure to be most likely due to conformational rigidity of the binding fragment of the E3-binding domain of E3BP and its exquisite amino acid match with the E3 target interface PMID: 16263718
- A cluster of disease-causing E3 mutations located near the center of the E3BD/E3 interface prevents the efficient recruitment of these E3 variants by E3BP into the PDC, leading to the dysfunction of the PDC catalytic machine. PMID: 16442803
- These data provide an additional case of E3BP deficiency with a unique and previously unreported deletion in the PDHX gene. PMID: 16566017
- Despite the presence of antibodies reactive with PDC-E3BP in the majority of primary biliary cirrhosis (PBC) patients this self-protein is not a dominant T-cell autoantigen in PBC. PMID: 16629643
- PDHX-assisted photosensitization with rose Bengal induces structural and functional alteration of mitochondria in HeLa cells. PMID: 17024456
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相關(guān)疾病:Pyruvate dehydrogenase E3-binding protein deficiency (PDHXD)
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亞細胞定位:Mitochondrion matrix.
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蛋白家族:2-oxoacid dehydrogenase family
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數(shù)據(jù)庫鏈接:
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