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PIK3AP1 Antibody, Biotin conjugated

  • 中文名稱：
    PIK3AP1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA747806LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PIK3AP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PIK3AP1 antibody; BCAPPhosphoinositide 3-kinase adapter protein 1 antibody; B-cell adapter for phosphoinositide 3-kinase antibody; B-cell phosphoinositide 3-kinase adapter protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Phosphoinositide 3-kinase adapter protein 1 protein (293-404AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
  • 基因功能參考文獻：
    1. Dimeric BCAP associates with the TIR domains of TLR2/4 and MAL/TIRAP, suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions. PMID: 27909057
    2. Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions PMID: 15893754
  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 組織特異性：
    Expressed in natural killer (NK) cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30034

    OMIM: 607942

    KEGG: hsa:118788

    STRING: 9606.ENSP00000339826

    UniGene: Hs.310456