PLEKHF2 Antibody
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中文名稱:PLEKHF2兔多克隆抗體
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貨號:CSB-PA884492ESR1HU
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) PLEKHF2 Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:110070J07Rik antibody; AA673237 antibody; FLJ13187 antibody; PH and FYVE domain containing protein 2 antibody; PH and FYVE domain-containing protein 2 antibody; PH domain containing family F member 2 antibody; PH domain-containing family F member 2 antibody; Phafin 2 antibody; Phafin-2 antibody; PHAFIN2 antibody; PKHF2_HUMAN antibody; pleckstrin homology domain containing, family F (with FYVE domain) member 2 antibody; pleckstrin homology domain containing, family F (with FYVE domain) member2 antibody; Pleckstrin homology domain-containing family F member 2 antibody; Plekhf2 antibody; ZFYVE18 antibody; Zinc finger FYVE domain containing protein 18 antibody; Zinc finger FYVE domain-containing protein 18 antibody
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宿主:Rabbit
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反應種屬:Human
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免疫原:Recombinant Human Pleckstrin homology domain-containing family F member 2 protein (1-249AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:Antigen Affinity Purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式:Liquid
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應用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關產(chǎn)品
靶點詳情
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功能:May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
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基因功能參考文獻:
- PtdIns(3)P binding to Phafin2 occurs with high affinity, triggering minor conformational changes in the protein. Taken together, these studies represent a platform for establishing the structural basis of Phafin2 molecular interactions and the role of the two potentially redundant PtdIns(3)P-binding domains of the protein in endomembrane compartments. PMID: 28152563
- These findings establish that lysosomal accumulation of Akt and Phafin2 is a critical step in the induction of autophagy via an interaction with phosphatidylinositol 3 phosphate. PMID: 24416124
- Phafin2 controls EGFR trafficking through early endosomes by facilitating endosome fusion in concert with EEA1. PMID: 22816767
- These results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells' responses to the extracellular cues. PMID: 19995552
- Results demonstrate that EAPF/Phafin-2 facilitates TNF-alpha-induced cellular apoptosis through an ER-mitochondrial apoptotic pathway. PMID: 18288467
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亞細胞定位:Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum.
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組織特異性:Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.
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數(shù)據(jù)庫鏈接:
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