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PLEKHO1 Antibody, FITC conjugated

  • 中文名稱：
    PLEKHO1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA706633LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PLEKHO1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PLEKHO1
  • 別名：
    C-Jun-binding protein antibody; Casein kinase 2-interacting protein 1 antibody; CK2 interacting protein 1 antibody; CK2 interacting protein 1 HQ0024c protein antibody; CK2-interacting protein 1 antibody; CKIP 1 antibody; CKIP-1 antibody; CKIP1 antibody; JBP antibody; OC120 antibody; Osteoclast maturation associated gene 120 protein antibody; Osteoclast maturation-associated gene 120 protein antibody; PH domain-containing family O member 1 antibody; PKHO1_HUMAN antibody; Pleckstrin homology domain containing family O member 1 antibody; Pleckstrin homology domain-containing family O member 1 antibody; PLEKHO1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
  • 基因功能參考文獻：
    1. we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations. PMID: 28402261
    2. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation. PMID: 28404913
    3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization. PMID: 28212865
    4. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging. PMID: 28083909
    5. High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis. PMID: 25966172
    6. New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL. PMID: 27840970
    7. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 for neoplastic prostate cells transformation. PMID: 26160174
    8. CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta;-CBM-NF-kappaB signaling. PMID: 24465689
    9. CKIP-1 controlled Smurf1 expression in colon cancer PMID: 23995790
    10. overexpression triggers classical monocyte activation and transactivation of the TNF promoter PMID: 23583459
    11. CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1-Rpt6 interaction. PMID: 23032291
    12. CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW PMID: 22878216
    13. The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling. PMID: 20171213
    14. examination of CK2alpha for a region that mediates interactions with CKIP-1 revealed a putative HIKE domain; this motif by itself may not be sufficient to mediate interactions. PMID: 15254037
    15. CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein. PMID: 15831458
    16. Data provide evidence that ATM, a predominantly nuclear kinase, could be relocalized to the plasma membrane by CKIP-1. PMID: 16325375
    17. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
    18. The results provide a novel role of CKIP-1 in cytokine signaling response and the biochemical mechanism, by which two previously identified modulators IFP35 and Nmi are involved via interactions. PMID: 17197158
    19. Results indicate that CKIP-1, a novel Akt PH domain-interacting protein, would be a candidate of tumor suppressor with an Akt inhibitory function. PMID: 17942896
    20. CKIP-1 is cleaved by caspase-3 during apoptosis. C-terminal fragments translocate to the cytoplasm and nucleus and inhibit AP-1 activity via direct interaction with c-Jun and JunD. CKIP-1 also forms a feedback with caspase-3 and enhances apoptosis. PMID: 15706351
    21. CKIP-1 could interact with ATM and recruits nuclear ATM proteins partially to the plasma membrane. The results provide the first evidence that ATM, a predominantly nuclear kinase, could be re-localized to the plasma membrane. PMID: 16325375

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm.
  • 組織特異性：
    Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24310

    OMIM: 608335

    KEGG: hsa:51177

    STRING: 9606.ENSP00000358120

    UniGene: Hs.438824