Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PMAIP1 Antibody, Biotin conjugated

PMAIP1 Antibody, Biotin conjugated

  • 中文名稱：
    PMAIP1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA018229LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PMAIP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Adult T cell leukemia derived PMA responsive antibody; APR antibody; APR_HUMAN antibody; ATL-derived antibody; Immediate early response protein APR antibody; Immediate-early-response protein APR antibody; NOXA antibody; Phorbol 12 myristate 13 acetate induced protein 1 antibody; Phorbol-12-myristate-13-acetate-induced protein 1 antibody; PMA induced protein 1 antibody; PMA-induced protein 1 antibody; PMA-responsive gene antibody; Pmaip1 antibody; Protein Noxa antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Phorbol-12-myristate-13-acetate-induced protein 1 protein (1-136AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
  • 基因功能參考文獻(xiàn)：
    1. Data report that NOXA is a physiological substrate of autophagy. Mechanistic studies revealed that NOXA is hijacked by p62 for degradation during the autophagic process, and the three lysine residues at the C-terminus of NOXA are required for its autophagic degradation. Furthermore, autophagy can block apoptosis by eliminating NOXA in both p53-dependent and p53-independent manners. PMID: 29758299
    2. Fluorizoline increased the protein levels of the pro-apoptotic B-cell lymphoma 2 family member NOXA in chronic lymphocytic leukemia cells. Furthermore, fluorizoline synergized with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax to induce apoptosis. PMID: 28619845
    3. By ubiquitylating and degrading NOXA through activating CRL5, UBE2F selectively promotes lung cancer cell survival and could, therefore, serve as a novel cancer target PMID: 27591266
    4. Data show that Noxa-mediated MCL-1 phosphorylation and degradation is regulated by CDK2. PMID: 27166195
    5. the c-FLIP and NOXA/Mcl-1 axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells PMID: 28863158
    6. Noxa is involved in X-ray-induced lung injury. PMID: 27862899
    7. Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and acts synergistically with antimicrotubule drugs. PMID: 27521572
    8. knockdown of MCL-1 in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells PMID: 26680268
    9. high levels of miR21 expression may induce gastric cancer migration and invasion via the downregulation of Noxa expression PMID: 26847916
    10. Inhibition of SIRT1 could induce the Noxa expression in A549/DDP cells. PMID: 26903157
    11. Fluorizoline bind to prohibitin, inducing mitochondrial apoptotic pathway through NOXA and BIM upregulation. PMID: 26497683
    12. Noxa demethylation has a role in Bortezomib resistance in mantle cell lymphoma PMID: 25714012
    13. SATB1 as a Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes PMID: 26422397
    14. ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2. PMID: 25975837
    15. BCL2 and BCLX phosphorylation represents a priming event in mitotic cell death that is triggered by NOXA-dependent MCL1 degradation. The MCL1 decay allows in turn BIM-dependent cell death. PMID: 25922916
    16. Overexpression of nonphosphorylatable Noxa resulted in enhanced mitochondria-mediated apoptosis in the infected epithelium. PMID: 25404713
    17. Results reveal that oncogenic activation of MEK/ERK drives Noxa expression to promote autophagy, and suggest that Noxa has an indirect anti-apoptosis role in melanoma cells under nutrient starvation conditions. PMID: 25365078
    18. Overall, these data reveal a Noxa-mediated signaling pathway that couples lysosomal membrane permeabilization with mitochondrial outer membrane permeabilization and ultimate apoptosis during oxidative stress. PMID: 23770082
    19. CDK5 activity provides resistance to heat-induced apoptosis through the expression of miR-23a and subsequent suppression of NOXA synthesis PMID: 25829494
    20. Mcl-1/Noxa axis is important to overcome resistance to mitochondrial apoptosis in squamous cell carcinoma. PMID: 25210795
    21. Cells overexpressing HSP70 had higher levels of miR-23a, maintained these levels after heat shock and accumulated lower levels of NOXA mRNA and protein. PMID: 25429623
    22. Noxa upregulation reduces the availability of Usp9x to Mcl-1, thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells. PMID: 24991768
    23. Overexpression of ApoL2 did not induce cell death on its own. ApoL2 did not sensitize or protect cells from overexpression of the BH3-only proteins Bmf or Noxa. PMID: 24901046
    24. Noxa recruits MCL-1 from the cytosol to the mitochondria modulating ABT-737 sensitivity in small cell lung cancer. PMID: 24525728
    25. these results suggest that the C-terminal tail of Noxa regulates the stability of both Noxa and Mcl-1. PMID: 24811167
    26. Mantle cell lymphoma are characterized by high constitutive NOXA gene expression but low levels of NOXA protein. PMID: 24457957
    27. Parthenolide triggers extrinsic apoptosis by up-regulating TNFRSF10B and intrinsic apoptosis through increasing the expression of PMAIP1. PMID: 24387758
    28. Knockdown of TRAIL and Noxa reduced FOXO3-induced apoptosis, implicating that mitochondrial destabilization amplifies TRAIL-signaling. PMID: 23828551
    29. Physalin A-induced apoptosis was triggered by activation of p53-Noxa pathway. PMID: 23684722
    30. CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. PMID: 23798675
    31. caspases contribute to trigger the mitochondrial apoptotic pathway by coupling Bcl-2/Bcl-xL inhibition to that of Mcl-1, via the pRb/E2F-1-dependent induction of Noxa PMID: 23429261
    32. Vorinostat, is able to ablate the multicellular resistance to bortezomib by its ability to restore expression of a key pro-apoptotic Bcl-2 family member, Noxa. PMID: 23300762
    33. NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. PMID: 22361683
    34. Noxa is a central determinant of hypersensitivity to cisplatin PMID: 23302226
    35. Oncolytic viruses selectively induced expression of TRAIL and Noxa in prostate cancer cells, lung cancer cells, and breast cancer cells downstream of RIG-I and MAVS. PMID: 23014529
    36. Novel but opposing roles for the p53 and TAp73 in the induction of Noxa and Bim and regulation of apoptosis. PMID: 22430213
    37. Our results suggested that polymorphisms of NOXA and MCL1 may modify the risk of HPV16-associated oropharyngeal cancer. PMID: 22548841
    38. detailed analysis of the Noxa promoter revealed that p73 and Sp1-like factors, Sp1 and KLF6, played key roles in the transcriptional control of this gene PMID: 22718761
    39. these data suggest a new mechanism by which NOXA chemosensitized ovarian cancer cells to cisplatin by inducing alterations in the Bax/Smac axis. PMID: 22590594
    40. show that miR-200c is a novel negative regulator of the pro-apoptotic Bcl-2 family member Noxa PMID: 22615771
    41. during skin hypoxia, promotes UVB-induced apoptosis in keratinocytes PMID: 22245094
    42. siRNA-mediated knockdown of Noxa resulted in cell cycle arrest following E2 treatment, indicating that Noxa expression is required for cell cycle progression in ER-positive breast cancer cells. PMID: 22216287
    43. these study suggested that the four mutations lowered the stability of the p53 DBD domain and induced aggregation of structurally destabilized p53, and thus disrupted the p53-PUMA/NOXA interaction. PMID: 22446329
    44. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. PMID: 21628457
    45. Bortezomib can enhance sensitivity of NB4 cells to apoptosis induced by As(2)O(3) which may be related to up-regulation of proapoptotic protein NOXA. PMID: 21518486
    46. Noxa is critical for sensitivity to cell death induced by 2-deoxyglucose. This is the first evidence of the implication of a BH3-only protein in death induced by 2-DG. PMID: 21911456
    47. Noxa triggers the degradation of Mcl-1 at the mitochondria according to the exclusive location of Noxa at this compartment. PMID: 21907705
    48. Noxa/Mcl-1 balance is regulated by glucose deprivation as well as by general metabolic stress PMID: 21516346
    49. A pathway leading from the detection of viral RNA during modified vaccinia virus infection by the cytosolic helicase-pathway, to the up-regulation of Noxa and apoptosis via IRF3 and type I IFN signalling. PMID: 21698224
    50. Noxa participates in triggering mitochondrial dysfunction in multiple apoptotic pathways through distinct mechanisms PMID: 21113147

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    PMAIP1 family
  • 組織特異性：
    Highly expressed in adult T-cell leukemia cell line.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9108

    OMIM: 604959

    KEGG: hsa:5366

    STRING: 9606.ENSP00000326119

    UniGene: Hs.96