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PMM1 Antibody

  • 中文名稱：
    PMM1兔多克隆抗體
  • 貨號：
    CSB-PA018237LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: PMM1 antibody at 2µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: NIH/3T3 whole cell lysate
      Lane 3: 293T whole cell lysate
      Lane 4: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA018237LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PMM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PMM1
  • 別名：
    Brain glucose-1,6-bisphosphatase antibody; Phosphomannomutase 1 antibody; PMM 1 antibody; pmm1 antibody; PMM1_HUMAN antibody; PMMH 22 antibody; PMMH-22 antibody; PMMH22 antibody; Sec53 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Phosphomannomutase 1 protein (2-262AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PMM1 Antibody (CSB-PA018237LA01HU)，的標(biāo)記方式是Non-conjugated。對于PMM1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA018237LB01HU PMM1 Antibody, HRP conjugated ELISA
    FITC CSB-PA018237LC01HU PMM1 Antibody, FITC conjugated
    Biotin CSB-PA018237LD01HU PMM1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
  • 基因功能參考文獻(xiàn)：
    1. a triple mutant of phospomannomutase1 that retains mutase and phosphatase activity, but is unable to bind inosine monophosphate, was characterized. PMID: 29261720
    2. Mutations in phosphomannomutase is associated with ophthalmic manifestations of congenital disorder of glycosylation type 1a PMID: 12789572
    3. human alpha-phosphomannomutase 1 crystallographic structure reveals the structural basis of congenital disorder of glycosylation type 1a PMID: 16540464
    4. analysis of mental development in a patient with phosphomannomutase deficiency who is compound heterozygous for T237R/C241S mutations [case report] PMID: 17186415
    5. The genes GUS and PMM1 are recommended for normalization purposes in gene expression studies of liver tissue from patients with chronic hepatitis. PMID: 18591914
    6. PMM1 is responsible for the degradation of Glc-1,6-P(2) in brain PMID: 18927083

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Eukaryotic PMM family
  • 組織特異性：
    Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9114

    OMIM: 601786

    KEGG: hsa:5372

    STRING: 9606.ENSP00000216259

    UniGene: Hs.75835