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PMP2 Antibody, FITC conjugated

  • 中文名稱：
    PMP2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA07854C0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PMP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PMP2
  • 別名：
    FABP8 antibody; M FABP antibody; MP2 antibody; Myelin FABP antibody; Myelin P2 protein antibody; MYP2_HUMAN antibody; P2 antibody; Peripheral myelin protein 2 antibody; PMP2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Myelin P2 protein (1-132AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
  • 基因功能參考文獻(xiàn)：
    1. The structural characterization of the F57A mutant of P2 which shows changes in the portal region and helix alpha2 and an unfolded status upon lipid bilayer binding. Further results suggest a central role for Phe57 in regulating the opening of the portal region in human P2, and the F57A mutation disturbs dynamic cross-correlation networks in the portal region of P2. PMID: 29940944
    2. SH3TC2, PMP2, and BSCL2 pathogenic variants might be rare in Chinese Charcot-Marie-Tooth (CMT) patients. PMID: 29336362
    3. Our genetic and clinical findings in these kindred demonstrate that dominant PMP2 mutations cause Charcot-Marie- Tooth disease type 1. PMID: 27009151
    4. A fully deuterated sample of myelin P2 protein was produced identifying the neutron crystal structure. PMID: 26527266
    5. This report might expand the genetic and clinical features of Charcot-Marie-Tooth disease and a further mechanism study will enhance our understanding of PMP2-associated peripheral neuropathy. PMID: 26828946
    6. The structure of human P2 refined at the ultrahigh resolution of 0.93 A allows detailed structural analyses, including the full organization of an internal hydrogen-bonding network. PMID: 24419389
    7. the structure and function of the P2 protein from human myelin, which is able to bind both monomeric lipids inside its cavity and membrane surfaces PMID: 20421974

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9117

    OMIM: 170715

    KEGG: hsa:5375

    STRING: 9606.ENSP00000256103

    UniGene: Hs.571512