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POLR2C Antibody

  • 中文名稱：
    POLR2C兔多克隆抗體
  • 貨號(hào)：
    CSB-PA018329LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate, Mouse kidney tissue
      All lanes: POLR2C antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 32 kDa
      Observed band size: 32 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA018329LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA018329LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) POLR2C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    POLR2C
  • 別名：
    DNA directed RNA polymerase II 33 kDa polypeptide antibody; DNA directed RNA polymerase II subunit C antibody; DNA directed RNA polymerase II subunit RPB3 antibody; DNA-directed RNA polymerase II 33 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit C antibody; DNA-directed RNA polymerase II subunit RPB3 antibody; hRPB33 antibody; hsRPB3 antibody; POLR 2C antibody; POLR2 C antibody; Polr2c antibody; Polymerase (RNA) II (DNA directed) polypeptide C; 33kDa antibody; polymerase RNA II DNA directed polypeptide C 33kDa antibody; RNA polymerase II polypeptide C antibody; RNA polymerase II subunit 3 antibody; RNA polymerase II subunit B3 antibody; RPB 3 antibody; RPB3 antibody; RPB3_HUMAN antibody; RPB31 antibody; RPB33 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human DNA-directed RNA polymerase II subunit RPB3 protein (2-275AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，POLR2C Antibody (CSB-PA018329LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于POLR2C Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA018329LB01HU POLR2C Antibody, HRP conjugated ELISA
    FITC CSB-PA018329LC01HU POLR2C Antibody, FITC conjugated
    Biotin CSB-PA018329LD01HU POLR2C Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft.
  • 基因功能參考文獻(xiàn)：
    1. FUS low-complexicity phase separates to recruit RNA polymerase II C-terminal domain in vitro. PMID: 26455390
    2. These findings suggest that N-terminus of Rpb3 selectively inhibits Rpb3-high-expression hepatocellular carcinoma cells proliferation. N-terminus of Rpb3 may be useful in treating patients diagnosed with Rpb3-high-expression hepatocellular carcinoma. PMID: 25211001
    3. eEF1gamma, in addition to its role in translation elongation complex, is involved in regulating Vimentin gene by contacting both pol II and the Vimentin promoter region and shuttling/nursing the Vimentin mRNA PMID: 21217813
    4. interaction between RPB3 and ATF4 PMID: 12860379
    5. Rpb3 is a potential nuclear target of insulin-like growth factor binding protein-3 PMID: 16455777

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9189

    OMIM: 180663

    KEGG: hsa:5432

    STRING: 9606.ENSP00000219252

    UniGene: Hs.79402