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PPME1 Antibody

  • 中文名稱：
    PPME1兔多克隆抗體
  • 貨號：
    CSB-PA018501LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: PPME1 antibody at 2µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43, 23, 19, 44 kDa
      Observed band size: 43 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA018501LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PPME1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PPME1
  • 別名：
    PME 1 antibody; PME-1 antibody; PME1 antibody; PPME1 antibody; PPME1_HUMAN antibody; Protein phosphatase methylesterase 1 antibody; Testicular Secretory Protein Li 39 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein phosphatase methylesterase 1 protein (201-386AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PPME1 Antibody (CSB-PA018501LA01HU)，的標(biāo)記方式是Non-conjugated。對于PPME1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA018501LB01HU PPME1 Antibody, HRP conjugated ELISA
    FITC CSB-PA018501LC01HU PPME1 Antibody, FITC conjugated
    Biotin CSB-PA018501LD01HU PPME1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
  • 基因功能參考文獻(xiàn)：
    1. Authors found that PME-1 is exported from the nucleus to the cytoplasm upon H2O2 treatment and redistributes dem-p-PP2Ac in subcellular compartments. These findings offer new insight into the regulation of PME-1 localization and PP2A demethylation under oxidative stress. PMID: 30340029
    2. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK). PMID: 27810903
    3. Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A) activity by highly complex mechanisms. PMID: 27913678
    4. Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer. PMID: 27048286
    5. LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division PMID: 25839665
    6. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer. PMID: 24253382
    7. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
    8. GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 PMID: 22732552
    9. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. PMID: 21398589
    10. We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1. PMID: 17803990
    11. Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas. PMID: 19293187

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  • 蛋白家族：
    AB hydrolase superfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30178

    OMIM: 611117

    KEGG: hsa:51400

    STRING: 9606.ENSP00000329867

    UniGene: Hs.503251