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PPP1R11 Antibody, FITC conjugated

  • 中文名稱：
    PPP1R11兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA03834C0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PPP1R11 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PPP1R11
  • 別名：
    PPP1R11 antibody; HCGV antibody; TCTE5 antibody; E3 ubiquitin-protein ligase PPP1R11 antibody; EC 2.3.2.27 antibody; Hemochromatosis candidate gene V protein antibody; HCG V antibody; Protein phosphatase 1 regulatory subunit 11 antibody; Protein phosphatase inhibitor 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase PPP1R11 protein (1-126AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
  • 基因功能參考文獻：
    1. Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections PMID: 27805901
    2. a model in which I3 regulates an SDS22-mediated PP1 activation step in solution that precedes SDS22 dissociation and transfer of PP1 to kinetochores, and which is required for PP1 to efficiently antagonize Aurora B. PMID: 25298395
    3. Sds22 and Inhibitor-3 form a heterotrimeric complex with PP1, both in cell lysates and after purification. A pool of PP1 is complexly controlled by both Sds22 and Inhibitor-3. PMID: 17630778
    4. inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response PMID: 18450750
    5. Inh3 has two domains that are required for its interaction with PP1. PMID: 18951879

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  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 9285

    OMIM: 606670

    KEGG: hsa:6992

    STRING: 9606.ENSP00000365963

    UniGene: Hs.82887