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PPP2R2D Antibody, Biotin conjugated

  • 中文名稱：
    PPP2R2D兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA727750LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PPP2R2D Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    2ABD_HUMAN antibody; MDS026 antibody; PP2A subunit B isoform B55-delta antibody; PP2A subunit B isoform delta antibody; PP2A subunit B isoform PR55-delta antibody; PP2A subunit B isoform R2-delta antibody; PPP2R2D antibody; Protein phosphatase 2 regulatory subunit B delta antibody; Protein phosphatase 2 regulatory subunit B delta isoform antibody; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform protein (1-192AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能參考文獻：
    1. Results show that PPP2R2D expression was significantly upregulated at the mRNA and protein levels in gastric cancer (GC) tissues and correlated with poor prognosis. Further evidence demonstrates an oncogenic role of PPP2R2D in GC progression and development through regulation of mTOR. PMID: 29568966
    2. The PP2A regulatory subunit PPP2R2D inhibits T-cell proliferation and survival within tumors. PMID: 24596207
    3. The -462 G>A variant of PPP2R2D affects NF1 binding to the proximal promoter of PPP2R2D. PMID: 22539979
    4. These highly related members of the same subfamily of PP2A regulatory subunits differentially regulate TGF-beta/Activin/Nodal signalling to elicit opposing biological outcomes. PMID: 18697906
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphatase 2A regulatory subunit B family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23732

    OMIM: 613992

    KEGG: hsa:55844

    STRING: 9606.ENSP00000399970

    UniGene: Hs.380372