PRDX4 Antibody
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中文名稱:PRDX4兔多克隆抗體
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貨號:CSB-PA621653LA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產品詳情
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產品名稱:Rabbit anti-Homo sapiens (Human) PRDX4 Polyclonal antibody
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Uniprot No.:
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基因名:PRDX4
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別名:Antioxidant enzyme 372 antibody; Antioxidant enzyme AOE372 antibody; AOE37 2 antibody; AOE37-2 antibody; AOE372 antibody; EC 1.11.1.15 antibody; Peroxiredoxin IV antibody; Peroxiredoxin-4 antibody; Peroxiredoxin4 antibody; PRDX 4 antibody; Prdx4 antibody; PRDX4_HUMAN antibody; PRX 4 antibody; Prx IV antibody; Prx-IV antibody; PRX4 antibody; PrxIV antibody; Thioredoxin dependent peroxide reductase A0372 antibody; Thioredoxin Peroxidase (Antioxidant Enzyme) antibody; Thioredoxin peroxidase antibody; Thioredoxin peroxidase AO372 antibody; Thioredoxin-dependent peroxide reductase A0372 antibody; TRANK antibody
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宿主:Rabbit
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反應種屬:Human
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免疫原:Recombinant Human Peroxiredoxin-4 protein (38-271AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
本頁面中的產品,PRDX4 Antibody (CSB-PA621653LA01HU),的標記方式是Non-conjugated。對于PRDX4 Antibody,我們還提供其他標記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式:Liquid
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應用范圍:ELISA, WB
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關產品
靶點詳情
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功能:Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
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基因功能參考文獻:
- These features indicate that PRDX4 plays an important role in protecting against liver injury following BDL and might be a promising therapeutic modality for cholestatic diseases. PMID: 30149550
- Significant reduction in mRNA and protein levels of PrdxIV was observed in HEK293 cells overexpressing pathologically relevant recombinant mutant GNE protein (D207V and V603L) compared with vector control. Downregulation of PrdxIV keep the ER in a reduced (redox) state that may contribute to misfolding and aggregation of proteins in GNE myopathy. PMID: 28895049
- levels of peroxiredoxin 4 are higher in patients with prediabetes, but are similar in subjects with and without insulin resistance, which suggests that the main factor for its increased levels is hyperglycaemia and not insulin sensitivity state. PMID: 27303935
- Results show that ERp44 binds the oxidized but not the reduced form of Prx4; the ERp44-Prx4 complex is formed via thiol-disulfide interchange reactions, and its crystal structure reveals a redox-dependent recognition. PMID: 27642162
- Prdx4 expression was closely related to follicular development and has aprominent role in protecting human and mouse granulosa cells from reactive oxygen species damage. PMID: 26917265
- Positive Prx 4 expression is significantly correlated with recurrence and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma. PMID: 26261544
- An off-pathway reaction in the Prx4-mediated oxidative protein folding. PMID: 25137134
- Findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes PMID: 24893865
- Prx4 is a circulating antioxidant and is independently associated with increased risk of cardiovascular and all-cause mortality in T2DM. PMID: 24586984
- these data suggest an important role of Prdx4 in maintaining insulin levels and improving the ER folding capacity also under conditions of a high insulin requirement. PMID: 25122762
- there is a significant difference in concentration of Prx4 between cardiac arrest patients with good and poor outcome PMID: 24617620
- The structure and function of PRDX4 as well as its sensitivity to hyperoxidation. [Review] PMID: 24450625
- expression of PRDX4 in PCOS ovaries appeared to be mediated through oxidative stress in GCs. We reported that the deficiency of antioxidant PRDX4 was associated with pathophysiological mechanism of PCOS. PMID: 24098506
- peroxiredoxin IV recycling in the endoplasmic reticulum is much less efficient than in the cytosol or mitochondria, leading to the protection of peroxiredoxin IV from hyperoxidation. PMID: 24403061
- Remarkably, the Prx4-dependent formation of native disulfide bonds was accelerated when PDI was combined with ERp46 or P5, suggesting that PDIs work synergistically to increase the rate and fidelity of oxidative protein folding. PMID: 23949117
- Data indicate that protein disulfide isomerase (PDI) and ERp44 dynamically localize Ero1alpha and peroxiredoxin 4 in early secretory compartment (ESC). PMID: 23979138
- expression of Prxs I and IV, both at mRNA and protein levels, was associated with light chain secretion quantified by ELISA. PMID: 23737084
- Elevated serum Prx4 levels are associated with a significantly higher risk of incident cardiovascular disease (CVD) events or CVD mortality and all-cause mortality after adjustment for clinical risk factors. PMID: 23316297
- these results indicate that two placental proteins, Prx3 and Prx4, may act as new placental immune targets. Production of antibodies against peroxiredoxins 3 and 4 may introduce a new autoimmune hypothesis in recurrent pregnancy loss. PMID: 23190175
- data suggest that PRDX4 can be a novel target for glioblastoma multiforme therapies in the future PMID: 22916164
- Reverse phase protein arrays verified that the overexpression of both PRDX3 and PRDX4 in prostate tumor samples is negatively correlated with the presence of the TMPRSS2-ERG gene fusion. PMID: 22424448
- Prdx4 inhibits G-CSF-induced signalling and proliferation in myeloid progenitors. PMID: 22045733
- Overexpression of PRDX4 and P4HA2 was significantly associated with lymphatic metastasis in oral cavity squamous cell carcinoma PMID: 21859152
- Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle PMID: 21994946
- This study solved crystal structures of human Prx4 in three different redox forms and characterized the reaction features of Prx4 with hydrogen peroxide. PMID: 21916849
- Data show that Keap1 and PRDX IV were overexpressed in the TNBC cohort. PMID: 21693047
- A proteomic approach for identification and localization of the pericellular components of chondrocytes PMID: 21698479
- PRDXs exhibit differential expression in prostate tumors, with PRDX3 and 4 consistently upregulated. PMID: 21031435
- Elevated serum levels of the antioxidant Prx4 were associated with an increased disease severity and adverse outcome of critically ill patients with sepsis. PMID: 21283059
- strong reduction in PRDX4 expression levels in APL correlates with increased trimethylation of histone 3 lysine residue 27 and 4 at the transcriptional start site of PRDX4, indicative of a bivalent histone code involved in transcriptional silencing. PMID: 21283726
- Srx-Prx IV axis is critical for lung cancer maintenance and metastasis, suggesting that targeting the Srx-Prx IV axis may provide unique effective strategies for cancer prevention and treatment. PMID: 21487000
- PRDX4 has a pivotal protective function against diabetes progression in this type 1 diabetes mellitus model PMID: 20446767
- Here, the authors demonstrate that several members of the protein disulphide isomerase family are able to directly reduce this PrxIV disulphide and in the process become oxidized. PMID: 21057456
- These results suggest that Prdx-1 and Prdx-4 are essential for preventing respiratory syncytial virus-induced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epithelial cells. PMID: 20610706
- 2-Cys Prxs act in a mutually nonredundant and sometimes stress-specific fashion to protect human cells from oxidant injury. The substantial resistance of human cells to hydroperoxides may result in part from the additive action of multiple Prxs PMID: 12080185
- PRDX4 interacts with and regulates TBXA2R. PMID: 17644091
- Peroxiredoxin IV forms complex structures within the ER, consistent with the formation of homodecamers PMID: 18052930
- These results suggested that Prx IV involved in the 16alpha-OHE1-induced proliferation of MCF-7 cells has a proliferative effect and may be related to cancer development or progression. PMID: 18272409
- data suggested that TRAIL suppressed the PRDX4 gene at the transcriptional level and that downregulation of PRDX4 might facilitate cell death induced by TRAIL PMID: 19364504
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亞細胞定位:Cytoplasm. Endoplasmic reticulum.
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蛋白家族:Peroxiredoxin family, AhpC/Prx1 subfamily
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