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PREB Antibody

  • 中文名稱：
    PREB兔多克隆抗體
  • 貨號：
    CSB-PA018660GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Mammalian guanine nucleotide exchange factor mSec12 antibody; Preb antibody; PREB_HUMAN antibody; Prolactin regulatory binding element protein antibody; Prolactin regulatory element binding antibody; Prolactin regulatory element binding protein antibody; Prolactin regulatory element-binding protein antibody; SEC12 antibody
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PREB
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
  • 基因功能參考文獻(xiàn)：
    1. Administration of recombinant adenovirus containing human PREB to db/db, ob/ob, and DIO mice diminished glucose, insulin, and pyruvate tolerance indicating PREB to be a negative regulator of liver gluconeogenic genes. PMID: 29601978
    2. Wls-SEC12 binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt secretion. These data suggest that formation of early Wnt secretory vesicles is carefully regulated to ensure proper export of functional ligands PMID: 28515233
    3. These results indicate that PREB locates at the hepatitis C virus replication complex by interacting with NS4B. PMID: 26739056
    4. Sec12, a guanine-nucleotide exchange factor for Sar1 guanosine triphosphatase, is concentrated at endoplasmic reticulum exit sites and that this concentration of Sec12 is specifically required for the secretion of collagen VII but not other proteins. PMID: 25202031
    5. PREB regulates the cAMP-mediated transcription of the ABCA1 gene in vascular smooth muscle cells PMID: 20643408
    6. The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells. PMID: 19426980

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9356

    OMIM: 606395

    KEGG: hsa:10113

    STRING: 9606.ENSP00000260643

    UniGene: Hs.279784