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  4. PRR5 Antibody

PRR5 Antibody

  • 中文名稱：
    PRR5兔多克隆抗體
  • 貨號：
    CSB-PA018796GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Arhgap8 antibody; AU043908 antibody; C030017C09Rik antibody; C78947 antibody; FLJ20185 antibody; FLJ20185k antibody; MGC109513 antibody; MGC32512 antibody; PP610 antibody; Proline rich 5 (renal) antibody; Proline-rich protein 5 antibody; Protein observed with Rictor-1 antibody; Protor-1 antibody; PROTOR1 antibody; PRR5 antibody; PRR5_HUMAN antibody; PTOR1 antibody; Rho GTPase activating protein 8 antibody; RP1-181C9.3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PRR5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
  • 基因功能參考文獻：
    1. Fusion protein PRR5-ARHGAP8 plays a role in bipolar disorder with binge eating behavior. PMID: 29391396
    2. mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines PMID: 15718101
    3. It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 results in the co-immunoprecipitation of other mTORC2 subunits, but not Raptor, a specific component of mTORC1. PMID: 17461779
    4. The inhibition of Akt and S6K1 phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (PDGFRbeta). PMID: 17599906
  • 蛋白家族：
    PROTOR family
  • 組織特異性：
    Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 31682

    OMIM: 609406

    KEGG: hsa:55615

    STRING: 9606.ENSP00000384848

    UniGene: Hs.102336