PRSS1 Antibody, FITC conjugated
-
中文名稱:PRSS1兔多克隆抗體, FITC偶聯(lián)
-
貨號(hào):CSB-PA12309C0Rb
-
規(guī)格:¥880
-
其他:
產(chǎn)品詳情
-
產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) PRSS1 Polyclonal antibody
-
Uniprot No.:
-
基因名:PRSS1
-
別名:Alpha-trypsin chain 2 antibody; Beta-trypsin antibody; Cationic trypsinogen antibody; Digestive zymogen antibody; Nonfunctional trypsin 1 antibody; Prss1 antibody; Serine protease 1 antibody; TCR V beta 4.1 antibody; TRP1 antibody; TRY1 antibody; TRY1_HUMAN antibody; TRY4 antibody; TRYP1 antibody; Trypsin I antibody; Trypsinogen 1 antibody; Trypsinogen A antibody
-
宿主:Rabbit
-
反應(yīng)種屬:Human
-
免疫原:Recombinant Human Trypsin-1 protein (104-206AA)
-
免疫原種屬:Homo sapiens (Human)
-
標(biāo)記方式:FITC
-
克隆類型:Polyclonal
-
抗體亞型:IgG
-
純化方式:>95%, Protein G purified
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
-
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
-
基因功能參考文獻(xiàn):
- TF-FVIIa/trypsin-mediated PAR2 activation leads to enhanced MMP-2 expression in human breast cancer cells contributing to tumor progression. PMID: 29870887
- report here for the first time a family from India that is positive for R122H mutation in the PRSS1 gene PMID: 29476405
- Studied mutations in cationic trypsinogen (PRSS1) and serine protease inhibitor Kazal type 1 (SPINK1) and their association with alcoholic chronic pancreatitis (ACP) and idiopathic chronic pancreatitis. PMID: 29641165
- Data indicate association between polymorphism rs10273639 of the PRSS1-PRSS2 locus and pancreatitis development. PMID: 27846138
- SNP in the PRSS1-PRSS2-rs10273639 is associated with Chronic pancreatitis. PMID: 28913878
- Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations. PMID: 27409067
- Results identified 3 new rare variants in the proximal promoter region of PRSS1 which along the known c.-30_-28delTCC do not seem to be a risk factors for chronic pancreatitis. PMID: 27432637
- Early-onset pancreatitis is associated strongly with PRSS1 or CTRC mutations and family history of pancreatitis. PMID: 28502372
- PRSS1 variant p.L104P exhibits a variety of phenotypic changes that can increase risk for chronic pancreatitis. Mutation-induced misfolding and associated ER stress are the dominant effects that support a direct pathogenic role in chronic pancreatitis. PMID: 26822915
- Mutations in CFTR, SPINK1 or PRSS1 are present in one third of pediatric acute recurrent (ARP) or chronic (CP) pancreatitis with no other cause. PMID: 26692446
- Three types of pathogenic PRSS1 variants was identified in 11 patients, including p.N29I (n=1), p.R122H (n=1), and p.G208A (n=9). PMID: 27578509
- Mutations were found at the promoter and exon 3 of the PRSS1 in patients with pancreatic cancer. That is, five patients had c.410 C > T mutation causing p.Thr 137 Met, and three patients had c. -338 T >G mutation at the promoter of the PRSS1. In patients with PRSS1 mutations, serum trypsin was significantly higher than that in normal controls PMID: 26546433
- These findings suggest that IL-1beta plays a key role in trypsin upregulation and has a pathological role in multiple organ failure in influenza virus infection. PMID: 27714503
- Human anionic trypsinogen is controlled by CTRC in a manner that individual natural mutations are unlikely to increase stability enough to promote intra-pancreatic activation. PMID: 27129265
- Association of PRSS1 polymorphism with idiopathic recurrent acute pancreatitis and idiopathic chronic pancreatitis. PMID: 26110235
- Letter/Case Report: high penetrance of the PRSS1 A16V mutation caused by SPINK1 N34S and CFTR TG11-5T co-mutations associated with pancreatitis. PMID: 26658045
- We did not find PRSS1 mutation in any patient. PMID: 25981744
- In Israel, pediatric as well as adult recurrent acute pancreatitis and chronic pancreatitis are often associated with PRSS1, serine protease inhibitor Kazal type 1, chymotrypsin C, or Cystic Fibrosis Transmembrane Conductance Regulator mutations. PMID: 25383785
- This study shows that PRSS1, SPINK1 and CFTR mutations do not play a role in alcoholic and idiopathic chronic pancreatitis patients. PMID: 25835118
- N29T mutation associated with pancreatitis PMID: 26376395
- Recombination events between members of the trypsinogen family can generate high-risk PRSS1 alleles. PMID: 25546417
- the observations demonstrate that the tyrosyl sulfate in human trypsins interacts with the P2' position of the substrate-like inhibitor and this modification increases P2' selectivity towards basic side chains. PMID: 25010489
- PRSS1 single nucleotide polymorphism is associated with alcoholic pancreatitis. PMID: 25253127
- PRSS1 variants are associated with less disease relapse in autoimmune pancreatitis. PMID: 24909264
- Two novel PRSS1 mutations were identified in Mexican patients with early onset idiopathic recurrent acute pancreatitis. PMID: 25206283
- The -409 T/T genotype of PRSS1 gene was revealed to be a marker for predicting neotal sepsis, along with serum trypsin levels. PMID: 24777884
- None of the selected 121 pancreatic cancer samples showed a pancreatitis-predisposing mutation in the PRSS1 gene. PMID: 25003218
- expression of WT or mutant human PRSS1 in murine acinar cells induces apoptosis and is sufficient to promote spontaneous pancreatitis. PMID: 24722290
- Using the optimal cutoffs, the sensitivity of the IRT/PAP strategy would not be inferior to that of IRT/DNA if identification of mild forms is not required. PMID: 24513262
- PRSS1: IVS 2 +56_60 del CCCAG is a noval mutant which may contribute to AIP pathogenesis. PMID: 24236450
- The p.G208A variant of PRSS1, previously only found in Asian patients, was found in 3 generations of a European family, one of whom had chronic pancreatitis. PMID: 24413785
- the p.N43S mutation in the SPINK1 gene, accelerated the onset of HP in the presence of the p.R122H mutation in the CT gene. PMID: 24134754
- Rare causative PRSS1 mutations account for 9.1% of the idiopathic chronic pancreatitis study group in 253 young French patients. PMID: 23951356
- The trypsinogen to trypsin conformational switch modulates cleavage susceptibility of nick sites by altering both the thermodynamics and kinetics of cleavage to protect human cationic trypsin from premature degradation. PMID: 24403079
- PRSS1 hereditary pancreatitis is characterized by progressive lipomatous atrophy of the pancreas. PMID: 24525505
- No association of PRSS1 with pancreatic cancer is found. PMID: 23751316
- D21A polymorphism in the PRSS1 gene seems to be a risk factor for hereditary chronic pancreatitis. PMID: 23864476
- PRSS1 gene was significantly associated with total pancreatitis disease, both totally and separately PMID: 23801884
- For pediatric ulcerative colitis patients who require surgery, the immunopositivity of Tryp-1 at diagnosis is lower when compared to that of patients with a more benign disease course. PMID: 23745029
- Autoimmune pancreatitis may be related to PRSS1 gene mutations. PMID: 23745036
- Trypsin-1 and trypsin-2 appear to have a function in the degradation of vitreous type II collagen. PMID: 23882137
- A kindred from Venezuela, South America with the PRSS1 R122H variant. PMID: 23474566
- Even in the absence of chymotrypsin C, trypsinogen activation peptide mutants autoactivated at markedly increased rates. PMID: 23601753
- Case Report: suggest involvement of PRSS1 mutations in familial solid pseudopapillary pancreatic tumors. PMID: 22722260
- Frequencies of CFTR variants p.R75Q, p.I148T, 5T-allele and p.E528E were comparable in patients and controls. We identified 103 CFTR variants, which represents a 2.7-fold risk increase (p<0.0001). PMID: 22427236
- Two associations with alcoholic pancreatitis at genome-wide significance were identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. PMID: 23143602
- Data show that among the 2 mutations in the PRSS1 gene, only the N29I mutation was found in 1 (1.7%) of 58 patients with AP, in the heterozygous state. PMID: 22699143
- hereditary pancreatitis is caused by CTRC-dependent dysregulation of cationic trypsinogen autoactivation, which results in elevated trypsin levels in the pancreas. PMID: 22539344
- All of the heterozygote patients with a combination of CFTR and SPINK1 or PRSS1 mutations had chronic pancreatitis. PMID: 22094894
- Mutations of PRSS1 gene may be an important factor of pancreatic cancer. PMID: 22088471
顯示更多
收起更多
-
相關(guān)疾病:Pancreatitis, hereditary (PCTT)
-
亞細(xì)胞定位:Secreted, extracellular space.
-
蛋白家族:Peptidase S1 family
-
數(shù)據(jù)庫(kù)鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-