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PSMG1 Antibody, Biotin conjugated

  • 中文名稱：
    PSMG1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA018921LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PSMG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSMG1
  • 別名：
    PSMG1 antibody; C21LRP antibody; DSCR2 antibody; PAC1 antibody; Proteasome assembly chaperone 1 antibody; PAC-1 antibody; Chromosome 21 leucine-rich protein antibody; C21-LRP antibody; Down syndrome critical region protein 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Proteasome assembly chaperone 1 protein (91-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
  • 基因功能參考文獻：
    1. RNA-seq evidence of biallelic expression of PSMG1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of PSMG1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
    2. PSMG1 mutation is associated with Crohn's disease. PMID: 22593026
    3. Data show that an additive gene-gene interaction involving TLR4, PSMG1, TNFRSF6B and IRGM was identified with CD. PMID: 21079743
    4. PSMG1 gene expression is increased in classic variant of papillary thyroid carcinoma. PMID: 21509594
    5. The DSCR2 protein is associated with the endoplasmic reticulum; it is not an integral membrane protein and it is maintained on the cytoplasmic side of the ER by indirect interaction with the ER membrane or with another protein. PMID: 15590417
    6. Further, the results of intracellular localization studies and membrane fractionation assays indicate that DSCR2 is targeted to a cytoplasmic compartment as a soluble form. PMID: 15670775
    7. two chaperones, designated proteasome assembling chaperone-1 (PAC1) and PAC2, form a heterodimer and are involved in the maturation of mammalian 20S proteasomes PMID: 16251969
    8. DSCR2 was found to interact with PPARbeta and to inhibit it. PMID: 18793612

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  • 亞細胞定位：
    Cytoplasm. Endoplasmic reticulum.
  • 蛋白家族：
    PSMG1 family
  • 組織特異性：
    In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3043

    OMIM: 605296

    KEGG: hsa:8624

    STRING: 9606.ENSP00000329915

    UniGene: Hs.473838