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PTH2R Antibody

  • 中文名稱：
    PTH2R兔多克隆抗體
  • 貨號(hào)：
    CSB-PA018990LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunofluorescent analysis of U251 cells using CSB-PA018990LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PTH2R Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Parathyroid hormone 2 receptor antibody; Parathyroid hormone receptor precursor antibody; PTH 2 receptor antibody; PTH2 receptor antibody; Pth2r antibody; PTH2R_HUMAN antibody; Pthr 2 antibody; Pthr2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Parathyroid hormone 2 receptor protein (27-145AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PTH2R Antibody (CSB-PA018990LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PTH2R Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA018990LB01HU PTH2R Antibody, HRP conjugated ELISA
    FITC CSB-PA018990LC01HU PTH2R Antibody, FITC conjugated
    Biotin CSB-PA018990LD01HU PTH2R Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.
  • 基因功能參考文獻(xiàn)：
    1. expressed in the epidermis in Darier disease PMID: 28094886
    2. PTH2R and its ligand TIP39 regulate intracellular calcium and influence keratinocyte differentiation PMID: 27000502
    3. Authors report PTH2R as a gene that is disrupted in NSC. The disruption of the PTH2R gene may cause uncontrolled proliferation and differentiation of chondrocytes. PMID: 26044810
    4. Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine PMID: 24378925
    5. Data suggest role for PTH2R signaling in postnatal growth plate development and subsequent bone mass acquisition; overexpression of human PTH2R in chondrocytes of transgenic mice has key consequences on postnatal development of endochondral skeleton. PMID: 23092913
    6. specific interactions within the ligand-receptor bimolecular complex mediate distinct postactivation responses of class II G protein- coupled receptors and provide novel insights into the physiological regulation of PTH2R activity PMID: 14988434
    7. The distribution of PTH2R-immunoreactive fibers in viscerosensory brain regions is similar to that reported in mouse and rat suggesting a similar role of the PTH2R in human as in rodents. PMID: 18459453
    8. The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception. PMID: 19401215

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 組織特異性：
    Expressed abundantly in brain and pancreas. Also expressed in the testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9609

    OMIM: 601469

    KEGG: hsa:5746

    STRING: 9606.ENSP00000272847

    UniGene: Hs.570296